大鼠胚胎胰腺外分泌功能基因的表达调控

表2 E15.5-E18.5胰腺发育相关转录因子及相关信号分子差异表达谱

	探针号	GeneBank号	名称及相关功能	差异倍数(18.5/15.5)
bHLH	1387212_at	NM_012863	Muscle, intestine and stomachexpression 1(mist1)	7.46↑P/p
	1369803_at	NM_053964	Pancreas specific transcriptionfactor, 1a (Ptf1a) or Ptf1-P48	5.28↑P/p
ZF domain	1387894_at	L22761	GATA binding protein 4 (Gata4)	2↑P/p
	1368510_at	NM_012764	GATA binding protein 1(Gata1)	3.48↑P/p
	1368827_at	NM_019185.1	GATA-binding protein 6 (Gata6)	2.14↑P/p
HD	1369681_at	NM_017339	ISL1 transcription factor,LIM / homeodomain 1(Isl1)	2.64↑P/A
	1369516_at	NM_022852	Pancreatic and duodenal homeobox gene 1 (Pdx1)	1.74↑P/A
	1368873_at	NM_012581	Hoxa2	2.30↑P/p
	1388197_at	AA900970	Hoxa4	3.48↑P/A
	1370969_at	BE107303	Hoxa5	3.48↑P/P
Others	1371034_at	NM_022671	Hepatocyte nuclear factor 6	1.87↑P/p
	1368998_at	NM_031737	NK homeobox (Drosophila),family 6, A (NKX6.1)	2.14↓P/p

↑: 从E15.5到E18.5表达上升, ↓: 从E15.5到E18.5表达下降, P: 有表达, A: 无表达.