鼠肝炎病毒3型N蛋白I区激活 mfgl2凝血酶原酶基因

表1 MHV-A59, MHV-3, MHV-2和MHV-JHM的N蛋白氨基酸序列比较

		* G12S	* P38 del		P38L *	* NQN 40-42 del
MHV-A59	1	MSFVPGQENA	GGRSSSVNRA	GNGILKKTTW	ADQTERGPNN	QNRGRRNQPK	50
MHV-3		G	G
MHV-2		S	G		- - - -	H
MHV-JHM		S	G		L	K
					*E85Q
MHV-A59	51	QTATTQPNSG	SVVPHYSWFS	GITQFQKGKE	FQFAEGQGVP	IANGIPASEQ	100
MHV-3					E
MHV-2		A			Q	S
MHV-JHM					Q	Q
MHV-A59	101	KGYWYRHNRR	SFKTPDGQQK	QLLPRWYFYY	LGTGPHAGAS	YGDSIEGVFW	150
MHV-3					S
MHV-2					E
MHV- JHM			H		E
MHV-A59	151	VANSQADTNT	RSDIVERDPS	SHEAIPTRFA	PGTVLPQGFY	VEGSGRSAPA	200
MHV-3		NS	S
MHV-2		SQ K	TA V	K		K
MHV-JHM		SQ E R	SA
MHV-A59	201	SRSGSRSQSR	GPNNRARSSS	NQRQPASTVK	PDMAEEIAAL	VLAKLGKDAG	250
MHV-3				A
MHV-2
MHV-JHM		P
MHV-A59	251	QPKQVTKQSA	KEVRQKILNK	PRQKRTPNKQ	CPVQQCFGKR	GPNQNFGGSE	300
MHV-3
MHV-2			T
MHV-JHM						P
				*V321A
MHV-A59	301	MLKLGTSDPQ	FPILAELAPT	VGAFFFGSKL	ELVKKNSGGA	DEPTKDVYE	350
MHV-3
MHV-2				PS
MHV-JHM				A		G
MHV-A59	351	QYSGAVRFDS	TLPGFETIMK	VLNENLNAYQ	K-DGGADVVS	PKPQRKGRRQ	400
MHV-3					_
MHV-2		I		T	DQA SV L	P R
MHV-JHM					NQ	RGTK
MHV-A59	401	AQEKKDEVDN	VSVAKPKSSV	QRNVSRELTP	EDRSLLAQIL	DDGVVPDGLE	450
MHV-3
MHV-2			L
MHV-JHM		QKAQ
MHV-A59	451	DDSNV* .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. ..
500 MHV-3
MHV-2
MHV-JHM