Copyright
©The Author(s) 2004.
世界华人消化杂志. 2004-02-15; 12(2): 339-343
在线出版 2004-02-15. doi: 10.11569/wcjd.v12.i2.339
在线出版 2004-02-15. doi: 10.11569/wcjd.v12.i2.339
表1 肝硬化与正常肝组织基因表达差异情况
位置 | 比例 | 差值 | 基因 | 位置 | 比例 | 差值 | 基因 |
D7f | -46 583 | placenta growth factor | D3a | -13 878 | versican isoforms | ||
F5l | -45 246 | IL-inducible peptide | B1h | -13 644 | BAK | ||
F5e | 0.170 | -41 164 | IL-13 | A5b | 0.204 | -12 751 | MEK1 |
C4b | -40 337 | Wnt-5a | B3l | 0.153 | -12 644 | DAP kinase 1 | |
C7l | -39 092 | RAR gamma | D7i | 0.150 | -12 490 | GLG1 | |
E2f | 0.290 | -36 259 | emmprin | E6b | 0.422 | -12 411 | catenin alpha-2 |
C3i | 0.228 | -35 930 | Notch4 | F6k | -12 372 | TDGF1, 2, 3 | |
A3i | 0.080 | -33 464 | p19INK4d | D2c | -12 339 | collagen type XI | |
C7m | -32 988 | retinoid X receptor | A3j | -12 219 | WEE1HU | ||
D5f | -32 437 | CD9 | B1l | -11 664 | FLAME-1 | ||
B2g | 0.254 | -32 317 | TRIP | C2d | -11 434 | ERCC5 | |
C4k | 0.146 | -31 082 | DVL | A7n | -11 310 | desmin | |
B3j | -30 455 | caspase-10 | A5l | -11 230 | TFDP2 | ||
C2j | -30 318 | Rad | D2m | -11 077 | tenascin-C | ||
F2g | 0.388 | -30 177 | endothelin ET2 | F2f | -10 796 | EGF-like growth factor | |
E4j | 0.097 | -30 058 | CDC42 | D4f | -10 779 | GPIIIA; integrin beta3 | |
D5k | 0.085 | -28114 | ninjurin-1 | A7g | -10 686 | K4; CK4 | |
B7j | 0.250 | -27 838 | ABL2; ABLL | B2j | -10 436 | C-IAP2; IAP1; MIHC | |
E7n | -27 258 | HCK | A1c | 0.203 | -10 422 | CDPK3 | |
E2a | -26 725 | MMP-19 | A1e | -10 334 | kinase PSSALRE | ||
C6n | -26 592 | sex gene | F3j | 0.791 | -10 331 | EGR-1; KROX24; AT225 | |
E2d | 0.164 | -26 409 | TIMP-3; | B6d | -10 284 | p55-c-fgr protein | |
E5m | -26 206 | H-cadherin | C4n | -10 111 | smoothened | ||
D7g | -25 952 | FLT3/FLK2 | B7l | 0.265 | -9 485 | STAT1 | |
F5k | -25 326 | IFN-gamma | B7k | 0.444 | -9 301 | ZAP-70; ZAP70 | |
D5g | 0.170 | -25 132 | cytovillin 2 | E4n | 0.330 | -8 337 | P115 |
D6c | 0.281 | -23 356 | semaphorin E | B4c | 0.262 | -8 173 | WSL-LR; Apo-3 |
B3h | 0.465 | -23 309 | FLICE; CAP4; CASP8; MCH5 | D7n | 0.353 | -7 249 | homeobox HOX 4A |
C2n | 0.087 | -23 014 | replication factor C | A3m | 0.292 | -7 008 | NEDD5 protein homolog |
D4b | 0.136 | -22 957 | integrin alpha8 | C3e | 0.458 | -6 939 | RAD23 |
B2i | 0.122 | -21 022 | CRAF1 | A2e | 0.351 | -6 736 | PCTAIRE-3 |
E4e | -20 262 | P21-RAC2 | A5a | 0.367 | -6 249 | MAPKK 5; | |
B3i | 0.536 | -20 089 | ICE-LAP6 | E1k | 0.449 | -5 473 | MMP-14 (MT1-MMP) |
D5e | 0.159 | -19 823 | cytohesin-1 | A1i | 0.455 | -5 260 | P23; P25; P35 |
F3k | 0.137 | -19 389 | hepatocyte growth factor | C3b | 0.352 | -5 111 | superoxide dismutase 1 |
E1m | 0.095 | -19 179 | MMP-16 (MT3-MMP) | A4n | 0.464 | -4 929 | JNK3; JNK3; P49 |
D6f | -18 894 | semaphorin-1 | A7a | 0.352 | -4 649 | K16; CK 16; | |
E2b | 0.636 | -18 636 | TIMP-1; EPA | C1m | 0.380 | -4 399 | DNA TOPO I |
C3j | -18 316 | Jagged 1 | B4d | 0.473 | -4 221 | Akt1; c-Akt | |
C1a | -18 130 | DNA-PK; XRCC7 | A2f | 0.449 | -4 152 | PITALRE | |
C6m | -17 970 | CCK4; PTK7 | D2e | 2.162 | 10 343 | collagen type XVIII | |
B2n | 0.100 | -17 919 | TRAIL receptor | A5e | 1 0747 | PCNA; cyclin | |
D6h | -17 735 | LAR | E1e | 1.583 | 11 610 | MMP-8; collagenase-2 | |
A7d | -17 478 | K1; CK 1 | E3e | 2.141 | 1 1693 | NDK A; NM23-H1 | |
C2c | -17 212 | XRCC1 | D3f | 13 084 | fibronectin | ||
E1j | -17 010 | MMP-13; collagenase-3 | E6d | 14 470 | plakoglobin; | ||
F6b | -16 980 | NT-3 | E3l | 14 883 | rhoB | ||
B1k | 0.644 | -16 741 | NIK | D4j | 1.702 | 16 207 | integrin beta7 |
B3f | -16 474 | LICE2 | A7m | 16 433 | vimentin | ||
C5f | -15 882 | eps15 | D1b | 16 589 | byglycan | ||
D6e | -15 220 | semaphorin V | F4k | 16 800 | IL-5 | ||
B7g | -15 072 | SKY | D1a | 1.842 | 1 8757 | CSPCP; aggrecan 1; | |
A6f | -14 898 | b-raf | A6i | 1 9497 | c-myc binding protein | ||
B5l | 0.670 | -14 354 | rhoA | B5c | 19 662 | CD27BP (Siva) | |
E4i | 0.181 | -14 319 | p160ROCK | A3e | 28 403 | mda-6; CAP20 | |
F5d | -13 972 | IL-12 | F5n | 32 402 | MIF | ||
C1i | -13 927 | DNA polymerase | B5b | 36 045 | GST homolog | ||
A4j | 0.216 | -13 888 | ERK6; ERK5 |
引文著录: 刘连新, 陈志宏, 武林枫, 李宏伟, 刘芝华, 姜洪池, 王秀琴, 吴旻. 正常与硬化肝组织基因表达差异的初步分析. 世界华人消化杂志 2004; 12(2): 339-343