Photodynamic inhibitory effects of three perylenequinones on human colorectal carcinoma cell line and primate embryonic stem cell line

doi:10.3748/wjg.v9.i3.485

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Mar 15, 2003 (publication date) through Jun 4, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Colorectal Cancer

World J Gastroenterol. Mar 15, 2003; 9(3): 485-490
Published online Mar 15, 2003. doi: 10.3748/wjg.v9.i3.485

Table 1 The photochemical properties of the perylenequinones

Structure	UV λ_max (log ε)*	λ_max (log ε)*	φ ¹O₂
EA	459(1.60), 528(0.84), 568(1.04)	460(3.78), 531(3.13), 571(3.60)	0.94
HA	468(1.88), 542(0.83), 582(0.90)	417(5.51), 542(1.02), 582(7.70)	0.83
HB	470(0.27), 540(0.12), 583(0.13)	471(4.39), 543(3.01), 583(3.36)	0.76

Table 2 EA-induced apoptosis in R366.4 ES cells with FCM assay (means ± SD, n = 3)

Group	Rate of apoptosis/%
Group	5 min	6 min	10 min	20 min
Control	0	0	0	0
10^-7 Mol/L	0	0	0	0
10^-6 Mol/L	0	0	0	0
10^-5 Mol/L	0	0	0	0
10^-4 Mol/L	48.8 ± 4.50^b	50.3 ± 4.14^b	52.1 ± 2.35^b	50.5 ± 3.68^b
10^-3 Mol/L	54.9 ± 2.99^b	53.4 ± 4.01^b	52.4 ± 3.50^b	50.2 ± 4.93^b

^bP < 0.01, vs EA control.

Table 3 Hce-8693 cell apoptosis induced by photoactivated EA (means ± SD, n = 3)

Group	Rate of apoptosis/%
Group	10^-6 Mol/L	10^-5 Mol/L	10^-4 Mol/L	10^-3 Mol/L
Control	0	0	0	0
5 min	0	32.7 ± 7.56^b	53.6 ± 6.62^b	63.4 ± 10.24^b
6 min	0	19.3 ± 4.16^b	32.8 ± 7.38^b	55.5 ± 7.00^b
10 min	13.4 ± 3.25^b	26.4 ± 4.89^b	31.3 ± 5.39^b	44.9 ± 5.46^b
20 min	40.5 ± 8.58^b	52.7 ± 11.82^b	65.2 ± 11.22^b	68.0 ± 5.93^b

^bP < 0.01, vs EA control.

Table 4 Hce-8693 cell apoptosis induced by photoactivated HA (means ± SD, n = 3)

Group	Rate of apoptosis/%
Group	10^-6 Mol/L	10^-5 Mol/L	10^-4 Mol/L	10^-3 Mol/L
Control	0	0	0	0
5 min	29.5 ± 2.29^b	47.2 ± 8.79^b	48.4 ± 4.66^b	58.8 ± 8.40^b
6 min	32.0 ± 5.64^b	39.1 ± 6.41^b	43.2 ± 8.84^b	66.4 ± 8.02^b
10 min	40.2 ± 6.23^b	45.2 ± 8.40^b	45.5 ± 8.38^b	53.4 ± 8.77^b
20 min	22.6 ± 3.39^b	56.6 ± 3.86^b	62.8 ± 4.23^b	68.4 ± 8.85^b

^bP < 0.01, vs HA control.

Table 5 Hce-8693 cell apoptosis induced by photoactivated HB (means ± SD, n = 3)

Group	Rate of apoptosis/%
Group	10^-6 Mol/L	10^-5 Mol/L	10^-4 Mol/L	10^-3 Mol/L
Control	0	0	0	0
5 min	0	0	28.1 ± 6.21^b	64.8 ± 11.78^b
6 min	0	0	17.3 ± 3.68^b	32.0 ± 7.57^b
10 min	0	20.0 ± 4.21^b	20.5 ± 4.57^b	71.0 ± 10.57^b
20 min	13.7 ± 3.02^b	13.9 ± 2.87^b	19.1 ± 4.06^b	29.4 ± 6.56^b

^bP < 0.01, vs HB control.

Table 6 Comparison of antiproliferative effects of EA, HA and HB

Group	Rate of apoptosis/%
	10^-6 Mol/L			10^-5 Mol/L
	HA	EA	HB	HA	EA	HB
5 min	0	0	0	47.2 ± 8.79	32.7 ± 7.56	0
6 min	32.0 ± 5.64	0	0	39.1 ± 6.41	19.3 ± 4.16	0
10 min	40.2 ± 6.23	13.4 ± 3.25	0	45.2 ± 8.40	26.4 ± 4.89	20.0 ± 4.21
20 min	22.6 ± 3.39	40.5 ± 8.58	13.7 ± 3.02	56.6 ± 3.86	52.7 ± 11.82	13.9 ± 2.87

Citation: Ma L, Hong T, Li C, Zhang Y, Wang ZH, Ji WZ. Photodynamic inhibitory effects of three perylenequinones on human colorectal carcinoma cell line and primate embryonic stem cell line. World J Gastroenterol 2003; 9(3): 485-490
URL: https://www.wjgnet.com/1007-9327/full/v9/i3/485.htm
DOI: https://dx.doi.org/10.3748/wjg.v9.i3.485