Ameliorative effects of sodium ferulate on experimental colitis and their mechanisms in rats

Table 1 Effects of sodium ferulate on CMDI, HS and MPO activity in the colon tissue of acetic acid-induced rats colitis (n = 8, ¯x ± s)

Group	Dose (mg•kg-1)	CMDI	HS	MPO (U·g-1)
Normal	-	0.0 ± 0.0	0.7 ± 1.1	24.8 ± 11.5
Model	-	2.9 ± 0.6 d	4.3 ± 0.9 d	98.1 ± 26.9 d
5-ASA	100	1.6 ± 0.9b	3.4 ± 0.5a	29.6 ± 10.8b
SF	200	2.0 ± 0.8a	3.6 ± 1.2	79.5 ± 38.4
SF	400	1.8 ± 0.8b	3.3 ± 0.9a	63.8 ± 30.5a
SF	800	1.6 ± 0.9b	3.1 ± 1.0a	36.2 ± 14.2b

^aP < 0.05,

^bP < 0.01 vs model group; ^dP < 0.01 vs normal group.

Table 2 Effects of sodium ferulate on SOD activity, MDA and NO contents in the colon tissue of acetic acid-induced rats colitis (n = 8, ¯x ± s)

Group	Dose (mg·kg-1)	SOD (kU·g-1)	MDA (nmol·g-1)	NO (nmol·g-1)
Normal	-	36.14 ± 1.91	9.21 ± 3.85	176 ± 45
Model	-	28.33 ± 1.17 d	57.53 ± 12.36 d	331 ± 92 d
5-ASA	100	32.74 ± 3.52b	31.85 ± 11.72b	244 ± 51a
SF	200	31.63 ± 3.83a	43.25 ± 13.47a	256 ± 54
SF	400	32.15 ± 4.26a	41.84 ± 10.62a	247 ± 42a
SF	800	33.24 ± 3.69b	37.34 ± 8.58b	216 ± 33b

^aP < 0.05,

^bP < 0.01, vs model group; ^dP < 0.01 vs normal group.

Table 3 Effects of sodium ferulate on the content of PGE₂ and TXB₂ in the colon tissue of acetic acid-induced rats colitis (n = 8, ¯x ± s)

Group	Dose (mg·kg-1)	PGE2 (ng·g-1)	TXB2 (ng·g-1)
Normal	-	42.8 ± 32.8	8.83 ± 3.75
Model	-	186.2 ± 96.2 d	34.26 ± 13.51 d
5-ASA	100	67.0 ± 37.7b	18.53 ± 14.26a
SF	200	90.7 ± 52.3a	23.21 ± 12.46
SF	400	77.2 ± 26.9b	18.07 ± 14.83a
SF	800	58.4 ± 23.9b	15.52 ± 8.62b

^aP < 0.05,

^bP < 0.01 vs model group; ^dP < 0.01 vs normal group.