Effect of emodin and sandostatin on metabolism of eicosanoids in acute necrotizing pancreatitis

Table 1 Results of detection of metabolites of eicosanoids in 4 groups of rats with ANP (ng/L, mean ± SD)

Groups	TXB2			6-keto-PGF1α
	3 h	6 h	12 h	3 h	6 h	12 h
Emodin	290.16 ± 145.62(6)ad	335.63 ± 191.69(5)b	67.71 ± 38.54(6)b	111.70 ± 16.76(6)	127.68 ± 12.35(6)bc	79.09 ± 30.17(6)
Sandostatin	82.40 ± 21.59(7)b	193.98 ± 131.13(6)b	94.19 ± 19.29(6)a	117.62 ± 36.03(7)	111.96 ± 26.75(7)	72.04 ± 37.80(6)
Control	341.34 ± 230.26(6)	746.65 ± 141.88(6)	256.52 ± 124.97(6)	67.63 ± 29.25(7)	64.35 ± 21.80(6)	65.45 ± 20.54(6)
Sham-operat.	154.58 ± 38.73(5)a	165.35 ± 39.93(4)	148.63 ± 50.78(6)b	95.65 ± 28.59(5)	90.51 ± 13.97(4)	95.99 ± 34.66(6)

Notes: compared with in control group at the same time,

^aP ＜ 0.05,

^bP ＜ 0.01; compared with that in sham-operation group,

^cP ＜ 0.05,

^dP ＜ 0.01; (), the number of rats; PGE₂ is not listed because of no significant difference.

Table 2 Comparison of pathologic scores in SD rats with ANP 12 h after onset (mean ± SD)

Groups	n	Edema	Inflammation	Necrosis	Bleeding
Emodin	8	2.62 ± 0.53	2.94 ± 0.32	1.19 ± 1.13a	0.25 ± 0.46
Sandostatin	7	2.57 ± 0.34	2.71 ± 1.38	1.28 ± 0.45b	0.42 ± 0.53
Control	8	2.56 ± 0.42	3.75 ± 0.53	3.43 ± 0.62	0.63 ± 0.50

Notes: compared with control group,

^aP ＜ 0.05,

^bP ＜ 0.01.