Li H, Zhang JB, Chen XL, Fan L, Wang L, Li SH, Zheng QL, Wang XM, Yang Y, Chen GH, Wang GS. Different techniques for harvesting grafts for living donor liver transplantation: A systematic review and meta-analysis. World J Gastroenterol 2017; 23(20): 3730-3743 [PMID: 28611526 DOI: 10.3748/wjg.v23.i20.3730]
Corresponding Author of This Article
Gen-Shu Wang, MD, PhD, Professor, Department of Hepatic Surgery and Liver Transplantation Center of the Third Affiliated Hospital, Organ Transplantation Institute, Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, China. wgsh168@163.com
Research Domain of This Article
Transplantation
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Table 4 Results of meta-analysis comparison of minimally invasive living donor hepatectomy and conventional living donor hepatectomy
Outcome of interest
Study (n)
MILDH (n)
CLDH (n)
WMD/OR (95%CI)
P value
Study heterogeneity
P value
I2
df
I2, %
Graft weight (g)
5
123
119
-3.32 (-22.25,15.61)
0.73
6.56
4
39
0.16
Donor outcomes
Operative time (min)
13
476
1116
20.68 (-6.25,47.60)
0.13
147.62
12
92
< 0.01
Estimated blood loss (mL)
12
450
1092
-32.61 (-80.44,15.21)
0.18
61.26
11
82
< 0.01
Hospital cost (dollar)
2
36
36
0.56 (-0.62,1.74)
0.35
4.24
1
76
0.04
Length of hospital stay (d)
10
392
575
-1.25 (-2.35,-0.14)
0.03
99.31
9
91
< 0.01
Post complications
12
451
632
0.62 (0.44,0.89)
0.009
4.40
11
0
0.96
Analgesic use (h)
5
139
167
-7.97 (-14.06,-1.87)
0.01
7.50
4
47
0.11
Liver function
Post AST peak (IU/L)
7
334
471
6.41 (-3.79.16.60)
0.22
13.60
6
56
0.03
Post ALT peak (IU/L)
8
350
485
11.86 (-10.84,34.57)
0.31
15.39
7
55
0.03
Post TB peak (mg/dL)
7
324
461
-0.10 (-0.26,0.06)
0.21
2.10
6
0
0.91
Recipient outcomes
Liver function
Post AST peak (IU/L)
3
59
59
-28.73 (-86.76,29.31)
0.33
0.90
2
0
0.64
Post ALT peak (IU/L)
3
59
59
-29.98 (-87.65,27.7)
0.31
0.31
2
0
0.86
Post TB peak (mg/dL)
3
59
59
-0.96 (-2.57,0.65)
0.24
1.26
2
0
0.53
Surviving
3
0.96 (0.27,3.47)
0.95
0.11
2
0
0.95
Post complications
6
272
375
0.93 (0.66,1.31)
0.68
3.28
5
0
0.66
Citation: Li H, Zhang JB, Chen XL, Fan L, Wang L, Li SH, Zheng QL, Wang XM, Yang Y, Chen GH, Wang GS. Different techniques for harvesting grafts for living donor liver transplantation: A systematic review and meta-analysis. World J Gastroenterol 2017; 23(20): 3730-3743