CDX2 protein expression compared to alcian blue staining in the evaluation of esophageal intestinal metaplasia

Table 1 CDX2 and alcian blue pH 2.5 staining in in detecting intestinal metaplasia n (%)

Pathology1	Alcian blue	CDX2
BE, 108 biopsies	Positive, 108 (100)	Positive 102 (94.4)2
NBE, 48 biopsies	Negative, 43 (89.6), Positive, 5 (10.4)3	Negative 43, (89.6), Positive 5 (10.4)4
EG/CB, 43 biopsies	Positive, 43 (100)	Negative 43 (100)

¹199 total biopsies from 186 patients;

²6 BE biopsies lost focal intestinal metaplasia upon deeper sectioning for CDX2 immunohistochemistry;

³10.4% “false positives”, determined to be negative for CDX2 staining;

⁴Five of NBE biopsies tested positive for CDX2. BE: Barrett’s esophagus; NBE: Non-Barrett’s esophagus; EG: Esophageal glands; CB: Columnar blue cells.