Retrospective Study
Copyright ©The Author(s) 2015.
World J Gastroenterol. Feb 28, 2015; 21(8): 2419-2424
Published online Feb 28, 2015. doi: 10.3748/wjg.v21.i8.2419
Table 1 Potential factors affecting the levels of serum alanine aminotransferase and aspartate aminotransferase
FactorsALT
AST
Normal n = 3361Abnormal n = 408OR (95%CI)Regression coefficients orχ2valueP valueNormal n = 3677Abnormal n = 92OR (95%CI)Regression coefficients orχ2valueP value
Gender
Male1506 (44.8)292 (71.6)1.0342.1254< 0.00011739 (47.3)59 (64.1)1.0192.1106< 0.0001
Female1855 (55.2)116 (28.4)0.32 (0.26- 0.40)1938 (52.7)33 (35.9)0.50 (0.33-0.77)
Age146 ± 1943 ± 160.98 (0.98-0.99)-0.090700.001745 ± 1945 ± 161.00 (0.98-1.02)0.030950.0891
Drinking
No2220 (66.1)198 (48.5)1.02371 (64.5)47 (51.1)1.0
Previous53 (1.6)13 (3.2)2.75 (1.47-5.13)182.001< 0.000165 (1.8)1 (1.1)0.78 (0.11-5.71)120.0163< 0.0001
Current1088 (32.4)197 (48.3)2.03 (1.65-2.51)1241 (33.8)44 (47.8)1.79 (1.18-2.71)
Smoking
No2120 (63.1)238 (58.3)1.029.8714< 0.00012295 (62.4)63 (68.5)1.09.9796< 0.0001
Smoker1241 (36.9)170 (41.7)1.22 (0.99-1.50)1382 (37.6)29 (31.5)0.76 (0.49-1.19)
HBV
Negative3234 (96.2)365 (89.5)1.055.4066< 0.00013527 (95.9)72 (78.3)1.062.2821< 0.0001
Positive127 (3.8)43 (10.5)3.00 (2.09-4.31)150 (4.1)20 (21.7)6.53 (3.88-11.01)
HCV
Negative3330 (99.1)399 (97.8)1.010.48630.00123644 (99.1)85 (92.4)1.013.36290.0003
Positive31 (0.9)9 (2.2)2.42 (1.15-5.13)33 (0.9)7 (7.6)9.10 (3.91-21.14)
BMI22.2 ± 3.9123.67 ± 4.471.16 (1.13-1.20)1.17256< 0.000122.49 ± 3.7022.81 ± 4.331.07 (1.00-1.14)0.253930.0008
Cholesterol14.23 ± 1.24.57 ± 1.221.42 (1.28-1.56)3.01080< 0.00014.26 ± 1.204.50 ± 1.421.42 (1.19-1.70)1.37468< 0.0001
LDL12.90 ± 0.903.20 ± 0.901.37 (1.23-1.52)2.56544< 0.00013.00 ± 0.903.10 ± 1.101.23 (1.05-1.45)1.16700< 0.0001
HDL11.30 ± 0.401.30 ± 0.451.06 (0.90-1.25)-0.364830.59181.30 ± 0.401.40 ± 0.601.24 (1.03- 1.50)1.477880.0005
Triglyceride11.17 ± 0.971.76 ± 1.661.24 (1.17-1.30)2.03651< 0.00011.21 ± 1.051.51 ± 1.631.14 (1.07-1.22)0.93710< 0.0001
Table 2 Comparison between the new cut-off values and the old standards in men
StandardSensitivity (%)Specificity (%)P
ALTOld42.2394.52< 0.01
New88.7684.55< 0.01
ASTOld40.2195.53< 0.01
New84.3282.15< 0.01
Table 3 Upper normal limits of the levels of serum alanine aminotransferase and aspartate aminotransferase
GenderAreaSEPSensitivitySpecificityUpper normal limit
MenALT0.940.01< 0.050.890.8622.15
AST0.800.01< 0.050.850.8125.35
WomenALT0.900.006< 0.050.900.8222.40
AST0.840.008< 0.050.850.8024.25
Table 4 Comparison between the new cut-off values and the old standards in women
StandardSensitivity (%)Specificity (%)P
ALTOld58.1296.52< 0.01
New92.4585.25< 0.01
ASTOld49.1592.75< 0.01
New84.6280.34< 0.01