Association of colorectal cancer susceptibility variants with esophageal cancer in a Chinese population

Table 1 Characteristics of cases and controls in this study n (%)

Variable	Cases	Controls	P value
	(n = 360)	(n = 310)
Sex			< 0.001
Male	288 (62.0)	197 (36.5)
Female	72 (20.0)	113 (36.5)
Age, yr (mean ± SD)	60.7 ± 8.9	49.4 ± 7.9	< 0.001

Table 2 Allele frequencies in cases and controls and odds ratio estimates for esophageal cancer

SNP	Gene(s)	Locus	Alleles (A1/B)	Major allelic frequency		HWE P value	OR	95%CI	P value
				Case	Control
rs1912453	C1orf110	1q23.3	C/T	0.404	0.392	0.812	1.054	0.846-1.314	0.639
rs10911251	LAMC1	1q25.3	C/A	0.487	0.494	0.256	0.976	0.787-1.211	0.826
rs6687758		1q41	G/A	0.243	0.222	0.191	1.127	0.873-1.455	0.358
rs11903757		2q32.3	C/T	0.039	0.044	1.000	0.889	0.518-1.525	0.668
rs10936599	ARPM1	3q26.2	C/T	0.480	0.453	0.909	1.116	0.899-1.384	0.320
rs13130787		4q22.2	C/T	0.307	0.315	0.239	0.965	0.765-1.217	0.765
rs367615		5q21.3	T/C	0.447	0.431	0.908	1.070	0.861-1.328	0.542
rs647161		5q31.1	A/C	0.296	0.274	0.198	1.113	0.877-1.413	0.377
rs1321311		6p21.2	T/G	0.200	0.140	0.234	1.534	1.145-2.055	0.004
rs2057314	DCBLD1	6q22.1	C/T	0.483	0.455	0.302	1.120	0.901-1.391	0.308
rs9365723	SYNJ2	6q25.3	G/A	0.411	0.373	0.224	1.169	0.935-1.462	0.171
rs7758229	SLC22A3	6q25.3	T/G	0.229	0.268	1.000	0.811	0.632-1.042	0.101
rs39453		7p15.3	C/T	0.304	0.339	0.528	0.851	0.676-1.073	0.172
rs10505477	POU5F1B	8q24.21	T/C	0.431	0.435	0.205	0.983	0.791-1.221	0.874
rs6983267			G/T	0.425	0.437	0.490	0.950	0.765-1.181	0.645
rs7014346			A/G	0.288	0.323	0.438	0.848	0.672-1.071	0.167
rs10114408		9q22.32	T/A	0.160	0.177	0.175	0.881	0.662-1.174	0.388
rs1665650	HSPA12A	10q25.3	A/G	0.304	0.306	0.595	0.991	0.784-1.251	0.937
rs3824999	POLD3	11q13.4	C/A	0.370	0.379	0.542	0.961	0.768-1.202	0.726
rs3802842	C11orf93	11q23.1	C/A	0.421	0.451	0.065	0.885	0.712-1.100	0.272
rs10774214	CCND2	12p13.32	T/C	0.320	0.318	0.0262	1.011	0.803-1.274	0.923
rs3217901			G/A	0.482	0.498	0.113	0.936	0.755-1.161	0.548
rs59336	TBX3	12q24.21	T/A	0.417	0.379	1.000	1.171	0.939-1.461	0.160
rs7315438			T/C	0.361	0.342	0.528	1.085	0.866-1.360	0.478
rs4444235	BMP4	14q22.2	C/T	0.497	0.435	0.730	1.281	1.027-1.599	0.028
rs4779584	SCG5	15q13.3	C/T	0.216	0.190	0.716	1.175	0.899-1.537	0.237
rs9929218	CDH1	16q22.1	A/G	0.163	0.163	1.000	0.997	0.745-1.334	0.984
rs4939827	SMAD7	18q21.1	T/C	0.204	0.248	0.227	0.776	0.600-1.004	0.053
rs961253		20p12.3	A/C	0.107	0.102	0.537	1.062	0.747-1.510	0.737
rs2423279			C/T	0.359	0.344	0.0332	1.069	0.853-1.340	0.563
rs4925386	LAMA5	20q13.33	T/C	0.251	0.253	0.0102	0.987	0.770-1.265	0.916

¹Minor allele;

²Site with HWE P≤ 0.05 excluded. HWE: Hardy-Weinberg equilibrium; SNP: Single-nucleotide polymorphism.

Table 3 Logistic regression analysis of the association between the single-nucleotide polymorphisms and esophageal cancer risk n (%)

SNP	Model	Genotype	Cases	Controls	OR1 (95%CI)	P value	AIC	BIC
rs1321311	Codominant	G/G	226 (64.2)	226 (72.9)	1	0.004	670.6	693.0
		G/T	111 (31.5)	81 (26.1)	1.27 (0.84-1.93)
		T/T	15 (4.3)	3 (1.0)	8.06 (1.96-33.07)
	Dominant	G/G	226 (64.2)	226 (72.9)	1	0.066	676.1	694.1
		G/T-T/T	126 (35.8)	84 (27.1)	1.46 (0.97-2.19)
	Recessive	G/G-G/T	337 (95.7)	307 (99.0)	1	0.002	669.9	687.8
		T/T	15 (4.3)	3 (1.0)	7.51 (1.84-30.66)
rs4444235	Codominant	T/T	76 (23.5)	100 (32.4)	1	0.046	651.8	674.0
		C/T	174 (53.7)	149 (48.2)	1.69 (1.08-2.65)
		C/C	74 (22.8)	60 (19.4)	1.75 (1.01-3.02)
	Dominant	T/T	76 (23.5)	100 (32.4)	1	0.013	649.8	667.6
		C/T-C/C	248 (76.5)	209 (67.6)	1.71 (1.12-2.62)
	Recessive	T/T-C/T	250 (77.2)	249 (80.6)	1	0.350	655.0	672.8
		C/C	74 (22.8)	60 (19.4)	1.25 (0.79-1.98)
rs6687758	Codominant	A/A	212 (59.2)	183 (59.2)	1	0.066	679.0	701.5
		G/A	118 (33.0)	115 (37.2)	0.86 (0.58-1.28)
		G/G	28 (7.8)	11 (3.6)	2.40 (1.01-5.74)
	Dominant	A/A	212 (59.2)	183 (59.2)	1	0.950	682.4	700.4
		G/A-G/G	146 (40.8)	126 (40.8)	0.99 (0.68-1.44)
	Recessive	A/A-G/A	330 (92.2)	298 (96.4)	1	0.027	677.5	695.5
		G/G	28 (7.8)	11 (3.6)	2.54 (1.08-6.00)
rs3802842	Codominant	A/A	119 (33.4)	101 (32.8)	1	0.033	681.0	703.5
		C/A	174 (48.9)	136 (44.2)	0.91 (0.60-1.40)
		C/C	63 (17.7)	71 (23.1)	0.52 (0.31-0.88)
	Dominant	A/A	119 (33.4)	101 (32.8)	1	0.190	684.1	702.1
		C/A-C/C	237 (66.6)	207 (67.2)	0.77 (0.52-1.14)
	Recessive	A/A-C/A	293 (82.3)	237 (77.0)	1	0.010	679.2	697.1
		C/C	63 (17.7)	71 (23.1)	0.55 (0.34-0.87)
rs4939827	Codominant	C/C	228 (63.3)	179 (57.7)	1	0.110	687.0	709.5
		C/T	117 (32.5)	108 (34.8)	0.68 (0.46-1.02)
		T/T	15 (4.2)	23 (7.4)	0.58 (0.26-1.33)
	Dominant	C/C	228 (63.3)	179 (57.7)	1	0.038	685.1	703.2
		C/T-T/T	132 (36.7)	131 (42.3)	0.67 (0.46-0.98)
	Recessive	C/C-C/T	345 (95.8)	287 (92.6)	1	0.330	688.5	706.5
		T/T	15 (4.2)	23 (7.4)	0.67 (0.30-1.50)

¹Adjusted by sex and age. AIC: Akaike’s information criterion; BIC: Bayesian information criterion; SNP: Single-nucleotide polymorphism.