Yi JF, Li YM, Liu T, He WT, Li X, Zhou WC, Kang SL, Zeng XT, Zhang JQ. Mn-SOD and CuZn-SOD polymorphisms and interactions with risk factors in gastric cancer. World J Gastroenterol 2010; 16(37): 4738-4746 [PMID: 20872977 DOI: 10.3748/wjg.v16.i37.4738]
Corresponding Author of This Article
Yu-Min Li, Professor, Key Laboratory of Digestive System Tumors, Gansu Province, Lanzhou University Second Hospital, Lanzhou 730000, Gansu Province, China. lym19621225@hotmail.com
Article-Type of This Article
Brief Article
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Table 6 Interaction of SOD2 Val16Ala and environmental factors for gastric cancer development
Factors
SOD2
HC (%)
GC (%)
1OR (95% CI)
β
γ = βeg/βe
n = 147
n = 140
Alcohol
No
Val/Val
89 (60.5)
33 (23.6)
1.00
No
Ala/-
11 (7.5)
21 (15.0)
4.89 (2.11-11.36)
1.59
Yes
Val/Val
34 (23.1)
52 (37.1)
5.26 (2.62-10.55)
1.66
Yes
Ala/-
13 (8.8)
34 (24.3)
9.46 (4.08-21.94)
2.25
1.36
Family history
Negative
Val/Val
114 (77.6)
58 (41.4)
1.00
Negative
Ala/-
21 (14.3)
41 (29.3)
3.90 (2.09-7.27)
1.36
Positive
Val/Val
9 (6.1)
27 (19.3)
6.34 (2.75-14.59)
1.85
Positive
Ala/-
3 (2.0)
14 (10.0)
12.86 (3.36-49.25)
2.55
1.38
Type I H. pylori
Negative
Val/Val
75 (51.0)
23 (16.4)
1.00
Negative
Ala/-
7 (4.8)
9 (6.4)
4.90 (1.59-15.08)
1.59
Positive
Val/Val
48 (32.7)
61 (43.6)
4.24 (2.30-7.09)
1.44
Positive
Ala/-
17 (11.6)
47 (33.6)
9.07 (4.36-18.86)
2.21
1.53
Table 7 Interaction of SOD1 G7958A and SOD2 Val16Ala for gastric cancer development
Genotype
HC (%)
GC (%)
1OR (95% CI)
P
SOD1
SOD2
n = 147
n = 140
GG
Val/Val
72 (49.0)
31 (22.1)
1.00
A/-
Val/Val
50 (34.0)
54 (38.6)
2.54 (1.43-4.52)
0.002
GG
Ala/-
7 (4.8)
8 (5.7)
2.69 (0.89-8.14)
0.079
A/-
Ala/-
18 (12.2)
47 (33.6)
6.43 (3.20-12.91)
< 0.001
Citation: Yi JF, Li YM, Liu T, He WT, Li X, Zhou WC, Kang SL, Zeng XT, Zhang JQ. Mn-SOD and CuZn-SOD polymorphisms and interactions with risk factors in gastric cancer. World J Gastroenterol 2010; 16(37): 4738-4746