Effects of Haobie Yangyin Ruanjian Decoction on hepatic fibrosis induced by carbon tetrachloride in rats

doi:10.3748/wjg.v16.i12.1458

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Mar 28, 2010 (publication date) through Jun 4, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 28, 2010; 16(12): 1458-1464
Published online Mar 28, 2010. doi: 10.3748/wjg.v16.i12.1458

Table 1 Effect of HYRD on serum levels of ALT, AST, TP and Alb (mean ± SD)

Groups	ALT (U/L)	AST (U/L)	TP (g/L)	Alb (g/L)
Control	20.94 ± 8.76^b	26.11 ± 11.81^b	76.9 ± 13.1^a	36.3 ± 5.2^b
Model	62.40 ± 25.59	99.93 ± 38.76	45.8 ± 14.8	24.3 ± 5.3
Low-dosage HYRD group	47.92 ± 19.65	70.72 ± 28.53^a	53.2 ± 23.5	28.0 ± 7.4
Medium-dosage HYRD group	44.36 ± 20.50^a	74.06 ± 25.14^a	58.8 ± 24.9	30.6 ± 7.5^a
High-dosage HYRD group	34.29 ± 11.42^b	49.95 ± 19.47^b	67.1 ± 20.2^a	33.0 ± 5.6^b

^aP < 0.05,

^bP < 0.01 vs model group. HYRD: Haobie Yangyin Ruanjian Decoction; ALT: Alanine transaminase; AST: Aspartate transaminase; TP: Total protein; Alb: Albumin.

Table 2 Effect of HYRD on hepatic hydroxyproline content (mean ± SD)

Groups	Hydroxyproline(mg/g dry weight)
Control	0.18 ± 0.13^b
Model	2.39 ± 0.28
Low-dosage HYRD group	1.89 ± 0.99
Medium-dosage HYRD group	1.29 ± 0.56^b
High-dosage HYRD group	1.22 ± 0.45^b

^bP < 0.01 vs model group.

Table 3 Effect of HYRD on serum levels of PCIII, HA, LN and CIV (mean ± SD)

Groups	PCIII (μg/mL)	HA (ng/mL)	LN (ng/mL)	CIV (ng/mL)
Control	15.16 ± 15.12^b	205.30 ± 48.92^a	82.02 ± 8.86	21.71 ± 1.76
Model	35.73 ± 17.90	563.82 ± 335.54	89.57 ± 7.59	29.20 ± 6.17
Low-dosage HYRD group	27.87 ± 10.13	464.19 ± 283.41	79.86 ± 9.52	26.38 ± 8.61
Medium-dosage HYRD group	24.72 ± 10.87^a	256.46 ± 95.98^b	86.34 ± 8.30	24.41 ± 4.46
High-dosage HYRD group	20.34 ± 13.92^b	161.51 ± 48.29^b	83.26 ± 13.20	26.22 ± 7.97

^aP < 0.05,

^bP < 0.01 vs model group. PCIII: Type III precollagen; HA: Hyaluronic acid; LN: Laminin; CIV: Type IV collagen.

Table 4 Liver histopathological semi-quantitative scores (mean ± SD)

Groups	n	Scores					Staging scores
Groups	n	0	I	II	III	IV	Staging scores
Control	6	6					0.00 ± 0.00^b
Model	13				2	11	26.08 ± 5.85
Low-dosage HYRD group	9				4	5	16.72 ± 6.05^b
Medium-dosage HYRD group	11		1	3	5	2	12.77 ± 6.21^b
High-dosage HYRD group	11	1	3	5	2		4.86 ± 2.66^b

^bP < 0.01 vs model group.

Table 5 Expression of TGF-β1 and Smad3 (mean ± SD)

Groups	TGF-β1/β-actin	Smad3/β-actin
Control	1.00 ± 0.00^b	0.62 ± 0.08^b
Model	3.29 ± 2.08	1.33 ± 0.10
Low-dosage HYRD group	2.52 ± 1.57	1.20 ± 0.07^b
Medium-dosage HYRD group	2.14 ± 1.42	1.16 ± 0.05^b
High-dosage HYRD group	1.68 ± 0.51^a	0.79 ± 0.06^b

^aP < 0.05,

^bP < 0.01 vs model group. TGF: Transforming growth factor.

Citation: Yang FR, Fang BW, Lou JS. Effects of Haobie Yangyin Ruanjian Decoction on hepatic fibrosis induced by carbon tetrachloride in rats. World J Gastroenterol 2010; 16(12): 1458-1464
URL: https://www.wjgnet.com/1007-9327/full/v16/i12/1458.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i12.1458