Emerging role of microRNAs in liver diseases

Table 1 Expression of miRNAs in liver diseases

Liver	Upregulated	Downregulated	Ref.
HCV	miR-215, miR-16, miR-199, miR-155, miR-146	miR-122, miR-320, miR-191	[53]
HBV	miR-181a, miR-200b and miR-146a	miR-15a	[56]
Drug overdose	miR-711 (liver),	miR-29b(liver),	[62]
	Plasma: miR-122 miR-15a, miR-21, miR-101b, miR-148a and miR-192	miR-710 (plasma)
NAFLD	miR-122, miR-34a, miR-31, miR-103, miR-107, miR-194, miR-335-5p, miR-221 and miR-200a	miR-29c, miR-451, miR-21	[69,70]
ALD	miR-212, miR-320, miR-486, miR-705, and miR-1224	miR-27b, miR-214, miR-199a-3p, miR-182, miR-183, miR-200a, and miR-322	[71,72]
PBC	miR-328 and miR-299	miR-122a and miR-26a	[73]
Liver fibrosis	miR-27a, miR-27b,miR-30,	miR-9,miR-721 and miR-301	[80]
HCC	miR-18, miR-21, miR-221, miR-222, miR-224, miR-373 and miR-301	miR-122, miR-125, miR-130a, miR-150, miR-199, miR-200 and let-7 family members	[81,90-95]

HCV: Hepatitis C virus; HBV: Hepatitis B virus; NAFLD: Non-alcoholic fatty liver disease; ALD: Alcoholic liver disease; PBC: Primary biliary cirrhosis; HCC: Hepatocellular carcinoma.