Prognostic significance of S100A4 and vascular endothelial growth factor expression in pancreatic cancer

Table 1 Correlation analysis of S100A4 and VEGF expression in pancreatic cancer

S100A4	VEGF		P value
	(+)	(-)
(+)	30	8
(-)	7	17	< 0.001

Significance was estimated with χ² test.

Table 2 Correlation between S100A4 expression and clinicopathological parameters in pancreatic cancer, n (%)

Clinicopathological parameters	Cases (n)	S100A4 expression		P value
		Positive	Negative
Age (yr)
≥ 70	24	15 (62.5)	9 (37.5)
< 70	38	23 (60.5)	15 (39.5)	> 0.051
Gender
Male	36	22 (61.9)	14 (38.1)
Female	26	16 (61.5)	10 (38.5)	> 0.051
Differentiation
Well	17	12 (70.6)	5 (29.4)
Moderately	15	9 (60.0)	6 (40.0)
Poorly	30	17 (56.7)	13 (43.3)	> 0.051
Tumor size (cm)
< 2.0	3	0 (0)	3 (100)
2.0-4.0	38	21 (55.3)	17 (44.7)
> 4.0	21	17 (81.0)	4 (19.0)	< 0.052
Lymph node metastasis
(-)	13	5 (38.5)	8 (61.5)
(+)	49	33 (67.3)	16 (32.7)	> 0.051
Distant metastasis
(-)	39	23 (59.0)	16 (41.0)
(+)	23	15 (65.2)	8 (34.8)	> 0.051
TNM stage
I + II	30	14 (46.7)	16 (53.3)
III + IV	32	24 (75.0)	8 (25.0)	< 0.051

¹Significance was estimated with χ² test;

²Significance was estimated with Fisher’s exact test.

Table 3 Correlation between VEGF expression and clinicopathological parameters in pancreatic cancer, n (%)

Clinicopathological parameters	Cases (n)	VEGF expression		P value
		Positive	Negative
Age (yr)
≥ 70	24	17 (70.8)	7 (29.2)
< 70	38	20 (52.6)	18 (47.4)	> 0.05
Gender
Male	36	24 (66.7)	12 (33.3)
Female	26	13 (50)	13 (50)	> 0.05
Differentiation
Well	17	10 (58.8)	7 (41.2)
Moderately	15	8 (53.3)	7 (46.7)
Poorly	30	19 (63.3)	11 (36.7)	> 0.05
Tumor size (cm)
< 2.0	3	2 (66.7)	1 (33.3)
2.0-4.0	38	21 (55.3)	17 (44.7)
> 4.0	21	14 (66.7)	7 (33.3)	> 0.05
Lymph node metastasis
(-)	13	7 (53.8)	6 (46.2)
(+)	49	30 (61.2)	19 (38.8)	> 0.05
Distant metastasis
(-)	39	24 (61.5)	15 (38.5)
(+)	23	13 (56.5)	10 (43.5)	> 0.05
NM stage
I + II	30	17 (56.7)	13 (43.3)
III + IV	32	20 (62.5)	12 (37.5)	> 0.05

Significance was estimated with χ² test.

Table 4 Cox multivariate regression analysis of clinicopathological features as a prognostic predictor

	B	SE	Wald	df	P value	OR (95% CI)
Distant metastasis	1.101	0.345	10.163	1	0.001	3.006 (1.528, 5.914)
S100A4	0.893	0.338	6.989	1	0.008	2.443 (1.260, 4.736)
VEGF	0.821	0.340	5.815	1	0.016	2.272 (1.166, 4.426)