Predictive value of D-dimer for portal vein thrombosis after portal hypertension surgery in hepatitis B virus-related cirrhosis

Table 1 Characteristics of 52 patients studied

		Thrombus	Non-thrombus	P value
Age ( mean ± SD )		41.45 ± 10.83	44.3 ± 8.65	0.388
Gender	Male	15	31
	Female	2	4	0.649
Child's grade of Liver function	Grade A	6	12
	Grade B	10	21	0.997
	Grade C	1	2
Surgical procedure	Splenectomy	7	13
	Splenectomy + EVL1	9	19	0.923
	Splenectomy + ligation2	1	3

¹Refers to endoscopic variceal ligation;

²Refers to gastroesophageal devascularization.

Table 2 D-dimer level in the thrombosis and non-thrombosis groups (μg/mL)

	Before surgery	Day 1after surgery	Day 5 aftersurgery
Non-thrombus group	1 (0.5, 2)	4 (2, 8)1	4 (2, 4)12
Thrombus group	1 (0.5, 2)	4 (2, 8)1	8 (4, 8)13
Z value	1.863	0.318	3.264
P value	0.062	0.751	0.001

¹Refers to the higher level that is statistically significant after surgery than that before surgery;

²Refers to the lower level that is statistically significant before surgery than that one day after surgery;

³Refers to the higher level that is statistically significant before surgery than that one day after surgery.

Table 3 Diagnostic value for different D-dimer diagnostic standards (%)

		Sensitivity	Specificity	PPV	NPV
Qualitative standard	No decrease Increase	88.2 47.06	57.14 88.57	42.85 66.67	88.25 77.50
Semi-quantitative standard	> 0.5 > 1	1 1	0 0.05714	37.50 38.88	0 100
	> 2	0.8235	0.4858	49	82.00
	> 4	0.4118	0.8571	61.65	70.83
	> 8	0.2353	1	100.00	33.89
	> 16	0.2353	1	100.00	33.89