Anticancer effect of Jinlongshe granules on in situ-transplanted human MKN-45 gastric cancer in nude mice and xenografted sarcoma 180 in Kunming mice and its mechanism

Table 1 Anti-tumor effect of JLS granules on mice bearing S180

Group	n	Tumor weight (g)	Inhibition rate (%)
Control	10	4.67 ± 3.27	-
120 g/kg	10	1.94 ± 2.03ab	58.46
60 g/kg	10	2.32 ± 2.83ab	50.32
20 g/kg	10	2.76 ± 2.32ab	40.90
Cy	10	0.69 ± 0.33b	85.22

^aP < 0.05 vs Cy;

^bP < 0.01 vs control.

Table 2 Anti-tumor effect of JLS granules on MKN-45 cells in nude mice

Group	n	Tumor weight (g)	Inhibition rate (%)
Control	10	3.20 ± 0.96	-
120 g/kg	10	1.02 ± 0.57b	68.13
60 g/kg	10	1.41 ± 1.39b	55.94
20 g/kg	10	1.59 ± 1.12b	50.31
5-FU	8	1.49 ± 1.37b	53.43

^bP < 0.01 vs control.

Table 3 Effect of different treatments on cell cycle and apoptosis of MKN-45 cells (mean ± SD)

Group	n	G0/G1	G2/M	S	Apoptotic rate
Control	10	42.40 ± 11.28	21.28 ± 11.43	36.92 ± 12.21	19.88 ± 14.83c
120 g/kg	10	50.58 ± 8.78	26.45 ± 12.53	14.56 ± 9.35a	38.54 ± 12.65a
60 g/kg	10	47.55 ± 7.02	26.51 ± 15.05	19.36 ± 12.69a	28.27 ± 11.25
20 g/kg	10	46.37 ± 12.09	25.47 ± 14.79	24.04 ± 13.27a	22.81 ± 10.65c
5-FU	8	41.78 ± 4.30	23.59 ± 11.97	19.97 ± 13.31a	24.97 ± 9.93c

^aP < 0.05 vs control,

^cP < 0.05 vs 120 g/kg.