Oncogenic role of clusterin overexpression in multistage colorectal tumorigenesis and progression

doi:10.3748/wjg.v11.i21.3285

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Jun 7, 2005 (publication date) through May 26, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 7, 2005; 11(21): 3285-3289
Published online Jun 7, 2005. doi: 10.3748/wjg.v11.i21.3285

Table 1 Expression of clusterin in normal colorectal mucosa and in benign and malignant colorectal tumors¹.

	Informative cases	Clusterin
	Informative cases	Normal expression	Overexpression
Normal mucosa	76	76 (100%)	0 (0)
Adenoma	20	16 (83%)	4 (17%)
Primary carcinoma	85	46 (54%)	39 (46%)
Metastases	35	15 (43%)	20 (57%)

¹Values are n (%). A significant increasing frequency of overexpression of clusterin was observed in adenoma, in primary carcinoma and in metastatic lesion (P<0.01, χ² test for trend.

Table 2 Correlation of expression of clusterin and apoptotic index (AI) in colorectal carcinomas.

Clusterin	Apoptotic index (AI)
Clusterin	Informative case	High	Low	P¹
Overexpression (%)	37	8 (22)	29 (78)	<0.01
Normal expression (%)	46	24 (52)	22 (48)

¹χ² test.

Citation: Xie D, Sham JS, Zeng WF, Che LH, Zhang M, Wu HX, Lin HL, Wen JM, Lau SH, Hu L, Guan XY. Oncogenic role of clusterin overexpression in multistage colorectal tumorigenesis and progression. World J Gastroenterol 2005; 11(21): 3285-3289
URL: https://www.wjgnet.com/1007-9327/full/v11/i21/3285.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i21.3285