Association of FAS (TNFRSF6)-670 gene polymorphism with villous atrophy in coeliac disease

Table 1 Characteristics and genotype frequencies of FAS-G670A in untreated CD with villous atrophy

	CD (n = 146)	Controls (n = 203)	OR1 (95%CI)	OR2 (95%CI)	OR3 (95%CI)
Age (mean ± SD) yr.	38.7 ± 20.0	39.1 ± 11.9
Gender (F/M)	113/33	117/86
GG genotype (F/M)	25/9	31/11	1.08 (0.64-1.82)	2.44 (1.15-5.20)	0.75 (0.31-1.82)
GA genotype (F/M)	60/15	66/49	0.79 (0.51-1.22)	0.99 (0.57-1.75)	1.37 (0.63-2.99)
AA genotype(F/M)	28/9	20/26	1.30 (0.78-2.16)	0.46 (0.24-0.91)	0.88 (0.37-2.11)

F, women; M, men, OR¹, age and gender adjusted, CD vs controls, OR², age adjusted, F vs M in healthy controls, OR³, age adjusted, F vs M in CD.

Table 2 Association of severity of villous atrophy with FAS-G670A polymorphism in untreated CD

Marsh	Genotype analysis			Allelic analysis
	GG genotype	GA genotype	AA genotype	OR1(95%CI)	G allele (%)	A allele (%)	OR2(95%CI)
	F/M	F/M	F/M
IIIa (%)	3/3 (15.0)	17/6 (57.5)	6/5 (27.5)	Reference	35 (44.0)	45 (56.0)	Reference
IIIb (%)	9/5 (21.5)	25/7 (49.2)	15/4 (29.2)	1.63 (0.56-4.76)	60 (46.0)	70 (54.0)	1.10 (0.63-1.93)
IIIc (%)	13/1 (34.1)3	18/2 (48.8)	7/0 (17.1)	3.74 (1.19-11.82)	48 (58.5)	34 (41.5)	1.81 (0.97-3.38)

F, women; M, men, OR¹, adjusted, for GG genotype frequency;

³P = 0.025, OR², adjusted, for G allele frequency.