Effects of octreotide on acute necrotizing pancreatitis in rabbits

Table 1 Effects of octreotide on pancreatic level of MDA and endogenous scavengers in rabbits with NaTc-induced acute pancreatitis

	Control	NaTc	NaTc+octreotide
MDA (nmol/mg protein)	2.24 ± 0.51	7.52 ± 1.05a	4.14 ± 0.86ac
GSH (nmol/mg protein × 10-2)	2.76 ± 0.45	1.68 ± 0.24a	2.23 ± 0.48ac
GPx (U/mg protein × 10-2)	1.18 ± 0.34	0.53 ± 0.08a	0.82 ± 0.16ac
Catalase (U/mg protein × 10-4)	3.08 ± 0.54	2.79 ± 0.41a	3.16 ± 0.14ac
Mn-SOD (U/mg protein)	1.03 ± 0.22	0.43 ± 0.08a	0.53 ± 0.08a
Zn-, Cu-SOD (U/mg protein)	4.96 ± 0.76	3.34 ± 0.56a	4.12 ± 0.84ac

^aP < 0.05 vs control group;

^cP < 0.05 vs NaTc treated group.

Table 2 Effects of octreotide on histologic score in rabbits with NaTc-induced acute pancreatitis

Group	Vacuolization	Edema	Necrosis	Inflammation	Congestion
Control	0	0	0	0	0
NaTc	1.12 ± 0.16	2.00 ± 0.35	2.37 ± 0.42	3.15 ± 0.48	1.57 ± 0.33
NaTc+	1.57 ± 0.45	2.14 ± 0.32	2.43 ± 0.58	3.05 ± 0.36	1.50 ± 0.25
somatostatin