Inhibitory effect of all-trans retinoic acid on human hepatocellular carcinoma cell proliferation

Figure 1 Morphology of SMMC-7721 observed under trans-mission electron microscope. Untreated-cells have many microvilli, and their nuclei have a great of incisure (A). ATRA-treated cells have smaller volume, fewer microvilli on the surface, densed chromatin and increased heterochromatin. With the plasma increased, the nuclear/cytoplasmic ratio decreased. The mitochondria also increased. The Golgi com-plex became bigger. More vacuole and glycogen were seen. There were also many lipofuscin and tonofilaments (B).