Involvement of ATM/ATR-p38 MAPK cascade in MNNG induced G1-S arrest

doi:10.3748/wjg.v9.i9.2073

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Sep 15, 2003 (publication date) through Jan 23, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 15, 2003; 9(9): 2073-2077
Published online Sep 15, 2003. doi: 10.3748/wjg.v9.i9.2073

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Figure 2 MNNG exposure activates ATM/ATR in Vero cells. Increased phosphorylation of ATM/ATR was observed after 0.2 μM MNNG 2.5 h exposure. One activated substrate mo-lecular weight is about 38 kDa. Pretreatment with 100 μM wortmannin abrogated the upregulation. Positive control 4-NQO 2.5 mM 30 minutes.

Citation: Zhu KQ, Zhang SJ. Involvement of ATM/ATR-p38 MAPK cascade in MNNG induced G1-S arrest. World J Gastroenterol 2003; 9(9): 2073-2077
URL: https://www.wjgnet.com/1007-9327/full/v9/i9/2073.htm
DOI: https://dx.doi.org/10.3748/wjg.v9.i9.2073