Inhibition of hepatitis B virus by a novel L-nucleoside, β-L-D4A and related analogues

Figure 3 Inhibition on replication of extracellular HBV DNA by β-L-D4A. lanes 1, 2 as negative control; lanes 3, 4 as lamivudine at 1 μM; lanes 5, 6 as β-L-D4A at 10 μM; lanes 7, 8 as β-L-D4A at 2 μM; lanes 9, 10 as β-L-D4A at 0.4 μM; lanes 11, 12 as β-L-D4A at 0.08 μM; lanes 13, 14 as blank control (HepaG₂). RC: relaxed circular HBV DNA; SS: single-stranded HBV DNA.