Effect of gastrin on differentiation of rat intestinal epithelial cells in vitro

Figure 2 Ultrastructural changes of IEC-6 cells. a: Gastrin-treated cells (5000×, bar = 1 μm) showed columnar structures(the nuclei were shown by open arrows) with numerous microvilli on the edge (solid arrows). b: Gastrin-treated cells (12000×, bar = 500 nm)developed numerous microvilli (open arrows) and lots of endocytic vesicles appeared under the apical membrane (solid arrows). c: Control cells (5000×, bar = 1 μm) were thin and flat. Relatively large nuclei (open arrows) and scanty plasma were observed. d: Only sparse microvilli (open arrow) and endocytic vesicles (solid arrow) were seen in control cells (12000×, bar = 500 nm).