Effect of gastrin on differentiation of rat intestinal epithelial cells in vitro

Figure 1 Morphology of IEC-6 cells. a: Gastrin-treated cells(250×) contained an abundance of plasma, small nuclei with nucleoli, and were arranged regularly. b: One of gastrin-treated cells (400×) showed the tendency to form microvilli on the edge(open arrows), and cytoskeleton-like staining in plasma (solid arrows). c: Control cells (250×) contained sparse plasma, large nuclei without nucleoli, and were in irregular arrangement and immature shape. d: One of control cells (400×) showed no tendency to form microvilli on the edge, and nucleus was relatively larger and had no nucleolus.