Effects of neurotrophins on gastrointestinal myoelectric activities of rats

Table 1 Effects of neurotrophins (20 μg•kg-1) on gut myoelectric activity profiles 2 h before and 1 h after administration. (^-x±s)

Parameter	Site	n	NGF treatment		rm-BDNF treatment		rh-NT-3 treatment		Placebo treatment
			Before	After	Before	After	Before	After	Before	After
Frequency of spike bursts (min-1)	Antrum	5	1.6 ± 0.5	1.6 ± 0.5	1.6 ± 0.5	1.6 ± 0.5	1.6 ± 0.5	1.8 ± 0.6a	1.6 ± 0.5	1.6 ± 0.5
	Duodenum	5	16.2 ± 5.4	17.5 ± 5.8	15.9 ± 5.2	17.2 ± 5.9	16.3 ± 5.6	20.1 ± 9.3a	16.3 ± 5.4	16.5 ± 5.6
	Jejunum	5	12.1 ± 2.8	13.5 ± 3.4	11.9 ± 2.6	13.2 ± 3.7	12.2 ± 2.7	16.5 ± 7.1a	12.5 ± 2.9	12.4 ± 2.8
	Transverse colon	5	0.6 ± 0.1	0.8 ± 0.1a	0.6 ± 0.1	0.8 ± 0.1a	0.6 ± 0.1	0.9 ± 0.2b	0.6 ± 0.1	0.6 ± 0.1
	Distal colon*	3	0.5 ± 0.1	0.7 ± 0.1a	0.5 ± 0.1	0.7 ± 0.1a	0.5 ± 0.1	0.9 ± 0.2b
Amplitude of spike bursts (µV)	Antrum	5	180.2 ± 18.6	182.3 ± 19.1	181.3 ± 17.9	182.5 ± 20.4	180.6 ± 17.9	185.2 ± 22.1a	180.9 ± 18.8	180.4 ± 18.9
	Duodenum	5	306.5 ± 73.6	308.8 ± 72.7	306.7 ± 72.9	308.4 ± 72.4	306.5 ± 72.7	314.6 ± 81.8a	305.6 ± 74.2	306.2 ± 74.5
	Jejunum	5	295.8 ± 87.2	297.4 ± 88.5	296.5 ± 88.1	298.6 ± 89.3	295.6 ± 86.7	313.8 ± 98.3b	296.8 ± 87.3	295.8 ± 88.5
	Transverse colon	5	138.7 ± 32.1	142.5 ± 35.9a	139.4 ± 33.4	145.5 ± 38.8a	139.5 ± 33.3	160.3 ± 47.5b	137.9 ± 31.8	139.1 ± 32.5
	Distal colon*	3	142.9 ± 29.9	163.5 ± 40.1a	141.2 ± 27.3	160.5 ± 37.4a	142.6 ± 29.1	173.4 ± 35.4b
Duration of spike bursts (s)	Antrum	5	4.8 ± 1.1	4.8 ± 1.2	4.7 ± 1.2	4.9 ± 1.3	4.8 ± 1.2	4.9 ± 1.5	4.8 ± 1.2	4.8 ± 1.2
	Duodenum	5	6.5 ± 2.7	6.6 ± 3.1	6.5 ± 2.8	6.6 ± 3.2	6.5 ± 2.8	11.5 ± 6.8a	6.5 ± 2.8	6.5 ± 2.7
	Jejunum	5	6.7 ± 3.1	6.8 ± 3.2	6.7 ± 3.1	6.9 ± 3.4	6.8 ± 3.2	12.9 ± 8.3a	6.8 ± 3.2	6.8 ± 3.2
	Transverse colon	5	9.3 ± 2.2	14.3 ± 6.2a	9.3 ± 2.2	13.5 ± 7.2a	9.3 ± 2.3	15.3 ± 7.5a	9.3 ± 2.2	9.3 ± 2.3
	Distal colon*	3	12.7 ± 2.7	17.8 ± 3.8a	12.7 ± 2.7	19.7 ± 4.7a	12.7 ± 2.8	46.2 ± 7.3b
Intervals of MMC (min)	Antrum	5	10.1 ± 3.1	11.3 ± 4.0	10.2 ± 3.4	11.3 ± 4.3	10.1 ± 3.1	12.3 ± 6.2	10.3 ± 3.3	10.2 ± 3.1
	Duodenum	5	15.3 ± 5.4	16.9 ± 6.1	16.1 ± 5.5	17.2 ± 6.2	15.5 ± 5.5	17.3 ± 7.5	15.6 ± 5.5	15.6 ± 5.2
	Jejunum	5	16.8 ± 5.8	18.2 ± 7.4	17.1 ± 5.9	18.9 ± 7.6	16.8 ± 5.8	19.1 ± 9.1	16.4 ± 5.6	16.4 ± 5.6
	Transverse colon	5	18.4 ± 6.0	19.7 ± 6.1	19.3 ± 6.1	21.0 ± 7.5	18.9 ± 6.0	25.1 ± 11.1a	19.2 ± 6.2	19.7 ± 6.3
	Distal colon*	3	19.7 ± 4.1	22.2 ± 8.0	20.8 ± 5.3	23.5 ± 8.4	19.9 ± 4.2	-

^aP < 0.05,

^bP < 0.01 vs before, * There were 3 among 5 experimental rats in the three groups placed bipolar electrodes at distal colon.