Meta analysis of propranolol effects on gastrointestinal hemorrhage in cirrhotic patients

Table 2 Point estimates and 95%CIs of the risk difference of death

	Prapranolol group		Control group		Risk difference and its 95%CI (%)
	Total	Death	Total	Death
Primary prevention
Pascal (1984)	34	1	35	13	-34 [-51, -17]
Mills (1987)	38	15	43	19	-5 [-26, 17]
Pascal (1987)	118	25	112	40	-15 [-26, -3]
Italian (1988)	85	30	89	22	11 [-3, 24]
Strauss (1988)	20	7	16	7	-9 [-41, 23]
Colman (1990)	23	6	25	7	-2 [-27, 23]
Andreani (1990)	43	13	41	18	-14 [-34, 7]
Conn (1991)	51	8	51	11	-6 [-21, 9]
Prova (1991)	68	7	72	14	-9 [-21, 3]
Subtotal	480	112	484	151	-9 [-18, -1]
Overall effect			Z = -2.11	P = 0.03
Secondary prevention
Burroughs (1983)	26	4	22	5	-7 [-30, 15]
Lebrec (1984)	38	3	36	8	-14 [-30, 2]
Cerbelaud (1986)	42	5	42	12	-17 [-33, 0]
Villeneuve (1986)	42	19	37	14	7 [-14, 29]
Queuniet (1987)	51	12	48	13	-4 [-21, 14]
Marbet (1988)	10	1	10	3	-20 [-54, 14]
Colombo (1989)	32	4	30	7	-11 [-30, 8]
Sheen (1989)	18	0	18	2	-11 [-28, 6]
Garden (1990)	38	14	43	19	-7 [-29, 14]
Colman (1990)	26	1	26	1	0 [-10, 10]
Perez-Ayuso (1991)	26	4	28	7	-10 [-31, 12]
Calès (1999)	102	9	104	10	-1 [-9, 7]
Subtotal	451	76	444	101	-5 [-9, -1]
Overall effect			Z = -2.26	P = 0.02
All trials
Total	931	188	928	252	-7 [-12, -3]
Overall effect			Z = -3.44	P = 0.0006