Study on the possibility of insulin as a carrier of IUdR for hepatocellular carcinoma-targeted therapy

Table 1 Values of Bmax and Kd of ¹²⁵I-insulin binding to insu-lin receptor in hepatocellular carcinoma and its adjacent liver tissue (mean ± SD for six identical experiments)

	High affinity sites		Low affinity sites
	Bmax (nmol·L-1)	Kd (nmol·L-1)	Bmax (nmol·L-1)	Kd (nmol·L-1)
Hepatocellular carcinoma	1.58 ± 0.16a	2.20 ± 0.66	0.36 ± 0.11	18.80 ± 7.85
Adjacent liver tissue	1.09 ± 0.51	2.21 ± 0.72	0.33 ± 0.74	17.89 ± 7.87

^aP < 0.05 vs adjacent liver tissue. Bmax was the maximal amount of ligand bound; Kd was the dissociation constant of the bind-ing site for the ligand.