Progress in searching for susceptibility gene for inflammatory bowel disease by positional cloning

Table 3 Data of association analysis for HLA

Ref	Year	Author	Subject	Region	Association with CD	Association with UC
R83	1995	Duerr RH	American UC	HLA-DR2		DRB1*1601-
R84	1995	Nakajima A	Japanese CD	DR, DQ, DP	(DRB1*0405,0410,DQA1*03,DQB1
					*0401,0402)+, (DQA1*0102,DRB1*
					1501,1302,DQB1*0602) -
R85	1996	Reishagen M	German CD	DRB1, DQA1, DQB1	DRB1*07+, DRB1*03-
R86	1996	Hesresbach D	French CD	HLA-I, HLA-II, TAP	DRB1*1302+, DRB1*04+c
R52	1996	Satsangi J	Europe IBD	DRB, DQB		DRB1*103+, DRB1*12+
R87	1996	Danze PM	French CD	DRB1, DQB1	(DQB1*0501, DRB1*07, 01)+
					(DQB1*0602/0603, DRB1*03)-
R88	1996	Heresbach D	French UC	HLA-II, TAP		DRB1*03-
R89	1997	Bouma G	Dutch IBD	HLA-DR		DRB1*15+, DRB1*13-
R90	1998	Fernandez AM	Spanish UC	DRB1		DRB1*1501+, DRB1*
R91	1998	Cariappa A	American CD	DRB, DQB, DPB	Haplotype DRB3*0301/DRB1*1302+	1502(severe)+
R92	1999	Bouma G	Dutch UC	DR, TNF-α, LT-α		DRB1*0103+, DRB1*15(female)+
R93	1999	Yoshitake S	Japanese IBD	DQ, DR, DP	DQB1*0402+, DRB1*1502-	(DRB1*1502,DRB5*0102,
						DQA1*0103,DQB1*06011,
						DPA1*0201,DPB1*0901)+,
						(DRB4*0101,DQA1*0302) -
R94	1999	Stokkers PC	Meta-analysis	DR, DQ, TNF-α	(DR7,DRB3*0301,DQ4)+, (DR2,DR3)-	(DR2, DR9, DRB1*0103)+, DR4 -
R95	1999	Hirv K	Estonians UC	DR, DQ, TNF-α		DRB1*1501+
R96	2001	Seki SS	Japanese UC	HLA-I, HLA-II		(MICA-TM-STR6, B52, DR2)+
R97	2002	Lantermann A	IBDa	DPA1	DPA1*02021(German)+
R98	2002	Orchard TR	Europe IBD	HLA-B, DR, TNF-α	Uveitis with (B*27,B*58,DRB1*0103)
R77	2002	Ahmad T	CDb	HLA-I, HLA-II	(DRB1*0701,CW*0802)+,
				TNF-α, LT-α, HSP70	DRB1*0103(fistula)+, DRB1*1501-

Note: UC = Ulcerative colitis; CD = Crohn disease; IBD = UC+CD;

^a, German, South Africa and South Korea IBD;

^b, white people CD;

^c, DRB1*04 is only associated with CD with no effect to cortexin; P value is uniformly set at ≤ 0.05; +, Positive association; -, Negative association.