Progress in searching for susceptibility gene for inflammatory bowel disease by positional cloning

Table 1 Data of linkage analysis

Ref	Author	Year	Subject	Scope	Linkage loci for IBD	Linkage loci for CD	Linkage loci for UC
R26	Hugot JP	1996	Caucasian CD	Autosome		16q(IBD1) +
R27	Satsangi J	1996	Northern european IBD	Autosome	7 +, 12 +, 3 ±	7 ± , 12 ± , 3 ±	7 +
R28	Cho JH	1998	American IBDa	Genome	(3q +,1p ± )(non-Jewish), (3q ± ,4q ± )e	16 ±	——
R29	Ma Y	1999	American CDa	Genome		14q ± , 17q ±e, 5q ±e
R30	Hampe J	1999	European IBDb	Genome	1 ± , 6 ± , X ±	10 ± , 12 ± , 16 ±	4 ± , X ±
R31	Duerr RH	2000	American CDa	Genome		14q +
R32	Rioux JD	2000	Canadian IBD	Genome	19p+, 5q+, 3p ± , 6p ±	5q +f , 19p +	19p ±
R33	Fisher SA	2002	European IBD	Genome	(6p+,1+,14+,18+)(male)	6p + (male)	6p + (male)
R34	Brant SR	1998	American CDa	3,7,12,16		16q(IBD1) ±
R35	Rioux JD	1998	Toronto IBD	3,7,12,16	——	——	——
R36	Curran ME	1998	European IBDb	12,16	——	12q ±	——
R37	Annese V	1999	Italian IBD	3,6,7,12,16	16q ±	16q ±	16q ±
R38	Vermeire S	2000	Belgian CD	3,7,12,16		——
R39	Dechairo B	2001	European IBD	3,6,7,	6p +	——	——
R40	Paavola P	2001	Finnish IBD	1,3,7,12,14,16	——	——	——
R41	Gavanaugh J	2001	IBDc	12,16	16q +	16q +	——
R42	Ohmen JD	1996	American IBDa	16	——	16q ±e	——
R43	Parkes M	1996	English IBD	16	——	16q ±	——
R44	CavanaughJA	1998	Australian CD	16		16q +(IBD1)
R45	Mirza MM	1998	Northern european UC	16			16q ± (IBD1)
R46	Porabosco P	2000	Italian IBD	16	16q +	16q +	16q +
R47	Brant SR	2000	American CD	16		16q +f , 16q ±
R48	Akollar PN	2001	Jewish CD	16		16q +f
R49	Van Heel DA	2002	European CD	16		——
R50	Zouali H	2001	European CD	16		16q +
R51	Hampe J	2002	European IBD	16	16p ±	16q +, 16p ±	——
R52	Satsangi J	1996	European IBD	6(MHC-II)	——	——	6p(MHC-II) +
R53	Silverber MS	1999	Canadian CD	6		6p(MHC-II) ±
R54	Hampe J	1999	Northern european IBDb	6	6p+	6p +	6p +
R55	Yang H	1999	American CD	6		6p(MHC) +
R56	Duerr RH	1998	Northern american IBD	12	12q ±	——	——
R57	Yang H	1999	American IBD	12	——	12q ±	——
R58	Lesage S	2000	Northern european CDd	12		——
R59	Parkes M	2000	American IBD	12	12q+	——	12q +
R60	Hampe J	2001	Northern european IBDb	3	——	——	——
R61	Duerr RH	2002	American IBD	3	3p +	——	——
R62	Rioux JD	2001	American CD	5q		5q +
R63	Vermeire S	2001	Belgian CD	X		Xq ±

Note: CD, CD-only family; UC, UC-only family; IBD=UC+CD+mixed family; +, convincing linkage (LOD ≥ 3.0); ±, suggestive linkage (3.0 > LOD ≥ 2.0); ——, no suggestive linkage (LOD < 2.0);

^a, including Jewish;

^b, family from English, German and Dutch;

^c, family from Northern American, European and Australian;

^d, family from French and Belgian;

^e, linkage only for Jewish;

^f, linkage only for IBD with early onset.