High level of deoxycholic acid in human bile does not promote cholesterol gallstone formation

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Jul 15, 2003 (publication date) through Nov 3, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical Research

World J Gastroenterol. Jul 15, 2003; 9(7): 1576-1579
Published online Jul 15, 2003. doi: 10.3748/wjg.v9.i7.1576

Table 2 Occurrence of crystals and lipid composition in gallbladder bile of patients with cholesterol gallstones and gallstone free subjects

Group (n)	Single stone% (n)	Crystals positive%(n)	Median nucleation time days, (range)(n)	Cholesterol mol%	Bile acid mol%	Phospholipids mol%	Total lipid concentration g/dl	Cholesterol saturation%
Total gallst one(122)	29 (116)	79 (112)	6(1-56)(46)	7.8 ± 0.3	68.6 ± 0.6	23.6 ± 0.4	9.4 ± 0.4	112 ± 4
High DCA (13)	42 (12)	73 (11)	14 (2-28) (4)	8.1 ± 0.6	68.1 ± 1.6	23.8 ± 1.2	8.2 ± 1.0	116 ± 10
Low DCA (109)	28 (104)	79 (101)	3 (1-56) (42)	7.8 ± 0.3	68.7 ± 0.6	23.6 ± 0.5	9.6 ± 0.5	112 ± 5
Gallstone free (46)	-	11^a (45)	17^a(1-35)(24)	5.8 ± 0.3^a	71.3 ± 0.8	22.9 ± 0.7	13.1 ± 0.6^a	79 ± 3^a

Notes: Mean values ± Standard Error of the Mean. n = Number of observations.

^aP < 0.0001 vs Total gallstone.

Citation: Gustafsson U, Sahlin S, Einarsson C. High level of deoxycholic acid in human bile does not promote cholesterol gallstone formation. World J Gastroenterol 2003; 9(7): 1576-1579
URL: https://www.wjgnet.com/1007-9327/full/v9/i7/1576.htm
DOI: https://dx.doi.org/10.3748/wjg.v9.i7.1576