A novel stop codon mutation in HBsAg gene identified in a hepatitis B virus strain associated with cryptogenic cirrhosis

Table 4 Comparison of nucleotide sequences and amino acid sequences of HBsAg gene among the 3 adw subtypes

Codon	4	9	14	24	29	45	47
Sequence(1)	ATC Ile	CTA Leu	GTG Val	AGA Arg	CCG pro	TCA Ser	CTA Leu
Sequence(2)	ATC Ile	CCA Pro	GTA Val	AAA Lys	CCA Pro	TCA Ser	GTA Val
Sequence(3)	ACA Thr	CTA Leu	GTG Val	AGA Arg	CCA Pro	GCT Ala	GTA Val
Codon	49	56	57	59	61	64	71
Sequence(1)	CCT pro	CCA His	ACC Thr	AAT Asn	TCA Ser	TCC Ser	GGT Gly
Sequence(2)	CTT Leu	CAA Glu	ATC Ile	AGT Ser	TAA stop	TGT Cys	GGT Gly
Sequence(3)	CTT Leu	CCA His	ACC Thr	AAT Asn	TCA Ser	TCT Ser	GGC Gly
Codon	82	83	85	94	99	100	110
Sequence(1)	ATA Ile	TTC Phe	TTC Phe	TTA Leu	GAT Asp	TAT Tyr	ATT Ile
Sequence(2)	ATC Ile	TGC Cys	TGC Cys	TTG Leu	GAC Asp	TAT tyr	CTT Leu
Sequence(3)	ATA Ile	TTC Phe	TTC Phe	TTG Leu	GAC Asp	TAC Tyr	CTT Leu
Codon	113	114	115	117	118	122	126
Sequence(1)	TCA Ser	ACA Thr	ACA Thr	AGT Ser	ACG Thr	AAA Lys	ACT Thr
Sequence(2)	TCA ser	TCA Ser	ACA Thr	AGC Ser	ACC Thr	AAC Lys	ACT Thr
Sequence(3)	ACA Thr	TCA Ser	ACT Thr	AGC Ser	ACG Thr	AAG Lys	ATT Ile
Codon	130	131	132	136	143	144	146
Sequence(1)	GGC Gly	AAC Asn	AAG Lys	TCA Ser	ACG Thr	GAT Asp	AAT Asn
Sequence(2)	GGA gly	ACC Thr	ATG Met	TCA Ser	ACG Thr	GAC Asp	AAC Asn
Sequence(3)	GGA Gly	ACC Thr	ATG Met	TCT Ser	TCG Ser	GAC Asp	AAC Asn
Codon	148	154	155	160	161	171	190
Sequence(1)	ACC Thr	TCG Ser	TCC Ser	AAA Lys	TAC Thr	TCT Ser	GTT Val
Sequence(2)	ACC Thr	TCA Ser	TCT Ser	AAA Lys	TAC Thr	TCT Ser	GTC Val
Sequence(3)	ACT Thr	TCA Ser	TCT Ser	AGA Agr	TTC Phe	TCC ser	GTT val
Codon	194	200	207	209	213	214	215
Sequence(1)	GCT Ala	TAT Thr	AGC Ser	GTG Val	ATA Ile	CCG Pro	CTC Leu
Sequence(2)	GTT Val	TTT Phe	AAC Asn	TTG Leu	ATG met	CCG Pro	CTG Leu
Sequence(3)	GTT val	TAT Thr	AAC Asn	TTG Leu	TTA Leu	CCT Pro	CTA Leu
Codon	222
Sequence(1)	CTC Leu
Sequence(2)	CTC Leu
Sequence(3)	CTT Leu

Sequence (1): adw subtype reported by Ono et al[9]. Sequence (2): The patient’s sequence. Sequence (3): The Chinese consensus sequence of adw subtype.