A novel stop codon mutation in HBsAg gene identified in a hepatitis B virus strain associated with cryptogenic cirrhosis

Table 1 Viral and clinical examination results of the patient

Item	Jan.1999	Apr.1999	Oct.1999	Aug. 2000	Nov. 2000	Mar. 2001
HBsAg	-	-	-	-	-	-
Anti-HBs	+	+	+	+	+	+
HbeAg	+		+	+	+	+
Anti-Hbe	-	-	-	-	-	-
Anti-HBc-IgG	+	+	+	+	+	+
Anti-HBc-IgM	+	-	-	-	-	-
HBV DNA	Nd	Nd	Nd	Nd	+	+
HBV DNA copies/ml	Nd	Nd	Nd	Nd	1.02 × 108	1.54 × 109
ALT (U/L)	49.0	56.9	67.1	74.4	69.0	68.6
Albumin (g/L)	42.3	40.4	38.5	40.3	41.5	40.8
Globulin (g/L)	28.6	30.7	28.5	34.4	31.9	32.6
Bilirubin (μmol/L)	18.9	23.2	28.6	25.8	27.7	28.4
Hemoglobin (g/L)	Nd	Nd	Nd	111	115	110
WBC (109/L)	Nd	Nd	Nd	2.1	2.8	2.6
Platelet (109/L)	Nd	Nd	Nd	26	58	40

Nd, not determiined; +, positive; -, negative. ALT, alanine aminotransferase; WBC, white blood cell.