Prognostic significance of expression of cyclooxygenase-2 and vascular endothelial growth factor in human gastric carcinoma

Table 3 Correlation between VEGF, MVD and clinicopathologic factors

Variables	n	VEGF n (%)		MVD
		Positive	P value	¯x ± s	P value
Gender
Male	168	88 (52.4)	NS	22.11 ± 9.14	NS
Female	64	34 (53.1)		24.21 ± 8.85
Tumor size (cm)
< 5 cm	163	87 (53.4)	NS	23.17 ± 9.53	NS
≥ 5 cm	69	35 (50.7)		23.69 ± 8.26
Depth of invasion
Mucosa or submucosa	94	26 (27.7)	< 0.01	18.08 ± 8.32	< 0.01
Muscularis propria	138	96 (69.6)		26.41 ± 8.44
Histology
Differentiated	129	70 (54.3)	NS	23.48 ± 9.01	NS
Undifferentiated	103	52 (50.5)		23.25 ± 9.06
Lymph node metastasis
Present	64	47 (73.4)	< 0.01	28.52 ± 4.39	< 0.01
Absent	168	75 (44.6)		19.73 ± 8.47
Vascular invasion
Present	39	29 (74.4)	< 0.01	28.94 ± 5.03	< 0.01
Absent	193	93 (48.2)		21.67 ± 9.12
Noncancerous tissue
CAG	30	3 (10.0)	NS	10.43 ± 4.22	NS
Atypical hyperplasia	30	5 (16.7)		11.56 ± 6.17

Notes: NS, not significant; CAG, chronic atrophic gastritis