NQO1 C609T polymorphism associated with esophageal cancer and gastric cardiac carcinoma in North China

doi:10.3748/wjg.v9.i7.1390

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Jul 15, 2003 (publication date) through Dec 25, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Esophageal Cancer

World J Gastroenterol. Jul 15, 2003; 9(7): 1390-1393
Published online Jul 15, 2003. doi: 10.3748/wjg.v9.i7.1390

Table 2 Relative risk of the NQO1 C609T homogenous null for ESCC and GCA development

Groups	NQO1 genotype		aOR (95%CI)^d
Groups	C/C+C/T n (%)	T/T n (%)
Healthy controls	138 (83.6)	27 (16.4)	aOR (95%CI)^d
ESCC patient	143 (74.1)	50 (25.9)^a	1.78 (1.04-2.98)
Family history of UGIC
Positive	60 (69.8)	26 (30.2)^b	2.20 (1.18-3.98)
Negative	83 (77.6)	24 (22.4)	1.46 (0.79-2.63)
GCA patient	95 (76.6)	29 (23.4)	1.44 (0.86-2.30)
Family history of UGIC
Positive	30 (66.7)	15 (33.3)^c	2.55 (1.21-5.23)
Negative	65 (82.3)	14 (17.7)	1.10 (0.80-1.34)

Note. ESCC: esophageal squamous cell carcinoma; NQO1:NAD(P)H: quinone oxidoreductase 1; UGIC: upper gastrointestinal cancer; a, b, c. The genotype frequency was significantly higher than that in healthy controls (a. χ² = 4.79, P = 0.028; b. χ² = 6.53, P = 0.011; c. χ² = 6.36, P = 0.012); d. The age, sex and smoking status adjusted relative risk of the NQO1 C609T homogenous null genotype (T/T) against the combination of the heterozygote (C/T) and homozygous wild type (C/C).

Citation: Zhang JH, Li Y, Wang R, Geddert H, Guo W, Wen DG, Chen ZF, Wei LZ, Kuang G, He M, Zhang LW, Wu ML, Wang SJ. NQO1 C609T polymorphism associated with esophageal cancer and gastric cardiac carcinoma in North China. World J Gastroenterol 2003; 9(7): 1390-1393
URL: https://www.wjgnet.com/1007-9327/full/v9/i7/1390.htm
DOI: https://dx.doi.org/10.3748/wjg.v9.i7.1390