Synergistic antitumor effect of TRAIL and doxorubicin on colon cancer cell line SW480

Figure 4 Subcellular morphology of SW480 cells under treatment of TRAIL (100 mg•l^-1), doxorubicin (0. 86 mmol•l^-1), or the combination of them. The electron microscopic morphology was observed after 24 h treatment at the given concentration.A: TRAIL (100 μg•l^-1) or doxorubicin (0.86 μmol•l^-1) alone didn't affect the morphology of cells, with complete construction and evenly distributed chromatin (× 5000). B: The combination of TRAIL (100 μg•l^-1) and doxorubicin (0.86 μmol•l^-1) induced apoptosis in many cells, presented as condensed chromatin, distributing along nuclear perimeter (× 15000).