Review
Copyright ©The Author(s) 2003.
World J Gastroenterol. Jun 15, 2003; 9(6): 1165-1169
Published online Jun 15, 2003. doi: 10.3748/wjg.v9.i6.1165
Figure 1
Figure 1 TLS two-step model in human cells. (1) The main replicase in humans, pol δ, has difficulty in replicating through cis-syn T-T cyclobutane dimmer and (6-4) T-T photoproduct. This recruits specialized polymerases such as pol η, pol ι to insert or misinsert deoxynucleotides, and then pol ζ functions as a mismatch extender. (2) Opposite the abasic site, pol ιor REV1 inserts a deoxynucleotide, and bypass of this lesion occurs when combined with pol ζ.