Copyright
©The Author(s) 2003.
World J Gastroenterol. Jun 15, 2003; 9(6): 1165-1169
Published online Jun 15, 2003. doi: 10.3748/wjg.v9.i6.1165
Published online Jun 15, 2003. doi: 10.3748/wjg.v9.i6.1165
Figure 1 TLS two-step model in human cells.
(1) The main replicase in humans, pol δ, has difficulty in replicating through cis-syn T-T cyclobutane dimmer and (6-4) T-T photoproduct. This recruits specialized polymerases such as pol η, pol ι to insert or misinsert deoxynucleotides, and then pol ζ functions as a mismatch extender. (2) Opposite the abasic site, pol ιor REV1 inserts a deoxynucleotide, and bypass of this lesion occurs when combined with pol ζ.
- Citation: Zhu F, Zhang M. DNA polymerase ζ: new insight into eukaryotic mutagenesis and mammalian embryonic development. World J Gastroenterol 2003; 9(6): 1165-1169
- URL: https://www.wjgnet.com/1007-9327/full/v9/i6/1165.htm
- DOI: https://dx.doi.org/10.3748/wjg.v9.i6.1165