Effects of melatonin on the expression of iNOS and COX-2 in rat models of colitis

Table 3 Effects of MT on the colonic expression of iNOS and COX-2 semi-quantitated in rats with experimental colitis (^¯x± s, n = 6)

Group	Doses(mg•kg-1)	iNOS		COX-2
		Acetic acid	TNBS	Acetic acid	TNBS
Normal control		0.3 ± 0.5	0.3 ± 0.5	0.2 ± 0.4	0.2 ± 0.4
Model control		2.2 ± 0.9b	2.3 ± 0.8b	1.8 ± 0.9b	2.2 ± 0.9b
Melatonin	2.5	1.3 ± 0.5c	1.5 ± 0.5c	1.2 ± 0.4	1.7 ± 0.8
Melatonin	5.0	0.5 ± 0.5d	1.2 ± 0.8c	1.0 ± 0.6	1.3 ± 0.8
Melatonin	10.0	0.3 ± 0.5d	0.7 ± 0.8d	0.5 ± 0.5 c	0.8 ± 0.8c

^aP < 0.05,

^bP < 0.01 vs. Normal control;

^cP < 0.05,

^dP < 0.01 vs. Model control.