Effects of melatonin on the expression of iNOS and COX-2 in rat models of colitis

Table 2 Effects of MT on the colonic NO and PGE₂ levels in rats with experimental colitis (^¯x± s, n = 8)

Group	Doses(mg•kg-1)	NO (μmol•g-1 tissue)		PGE2 (ng•g-1 tissue)
		Acetic acid	TNBS	Acetic acid	TNBS
Normal control		0.174 ± 0.044	0.287 ± 0.069	43.1 ± 32.1	43.1 ± 32.1
Model control		0.327 ± 0.090b	0.533 ± 0.068b	184.5 ± 96.3b	181.3 ± 51.7b
Melatonin	2.5	0.230 ± 0.017d	0.403 ± 0.042d	89.1 ± 59.1c	109.0 ± 33.3d
Melatonin	5.0	0.218 ± 0.018d	0.380 ± 0.029d	76.4 ± 23.6c	89.8 ± 37.7d
Melatonin	10.0	0.189 ± 0.029d	0.340 ± 0.019d	57.1 ± 23.2d	85.9 ± 39.2d

^aP < 0.05,

^bP < 0.01, vs. normal control;

^cP < 0.05,

^dP < 0.01 vs. model control.