Effects of melatonin on the expression of iNOS and COX-2 in rat models of colitis

Table 1 Effects of MT on CMDI in rats with experimental colitis (^¯x± s, n = 8)

Group	Doses (mg•kg-1)	CMDI
		Acetic acid	TNBS
Normal control		0.0 ± 0.0	0.0 ± 0.0
Model control		2.87 ± 0.64a	3.12 ± 1.12a
Melatonin	2.5	2.12 ± 0.83b	2.33 ± 0.51
Melatonin	5.0	1.75 ± 0.88c	1.66 ± 0.81b
Melatonin	10.0	1.12 ± 0.35c	1.75 ± 0.88b

^aP < 0.01 vs. Normal control;

^bP < 0.05,

^cP < 0.01 vs. Model control.