Is p53 gene mutation an indicatior of the biological behaviors of recurrence of hepatocellular carcinoma?

Table 5 Correlation between the clinical features of recurrent hepatocellular carcinoma and the presence of a p53 mutation in the primary lesion

The clinical features	P53 Positive(n = 49)	P53 Negative(n = 6)	P
Extrahepatic metastasis (number) (%)	24 (49.0)	3 (50.0)	0.1130
Multiple-recurrent tumors (number) (%)	34 (69.4)	4 (66.7)	1.0000
Extent of recurrent tumors:	34 (69.4)	5 (83.3)	0.0043
More than one segment (number) (%)
Median survival after recurrence (Months)	3.4	11.0	0.0510
Treatment for recurrent tumors
Surgery (number) (%)	0	1a (16.7)	n.s.
Non-surgicalb(number) (%)		20 (40.8)	3 (50.0)
No treatment (number) (%)		29 (59.2)	2 (33.3)

Notes: n.s.: no statistical significant;

^a: A 55 year old man had a resection of segment II and III;

^b: The Non-surgical treatments included transcatheter arterial chemoembolization and percutaneous ethanol injection.