Is p53 gene mutation an indicatior of the biological behaviors of recurrence of hepatocellular carcinoma?

Table 2 Comparison of characteristics between p53 positive and negative groups

Characteristics	P53 Positive(n = 64)	P53 Negative(n = 15)	P (UV)
Age (years)	52.8	48.3	n.s.
Male	65.6%	66.7%	n.s.
Liver cirrhosis	76.6%	53.3%	n.s.
Child class A	68.8%	73.3%	n.s.
Tumor < 3 cm	34.4%	13.3%	n.s.
> 10 cm	35.9%	40.0%	n.s.
HBsAg (+)	78.1%	66.7%	n.s.
Anti-HCV (+)	53.1%	46.6%	n.s.
AFP < 20 ng/mL	37.5%	40.0%	n.s.
> 1000 ng/mL	21.9%	40.0%	n.s.
Edmondson grade Ia	1.6%	20.0%	0.0203
Capsule complete	17.2%	46.7%	0.0346
Daughter nodules	60.9%	33.3%	0.0527
Vascular permeationb	78.1%	40.0%	0.0088

Notes: P (UV): The P value by univariate analysis; In multivariate analysis, the significant variables of

^a and

^b: P values were 0.0120 and 0.0420 respectively; HBsAg: hepatitis B surface antigen; Anti-HCV: antibody to hepatitis C virus; AFP: alpha-fetoprotein; Edmondson grade: Edmondson-Steiner grade of cellular differentiation; n.s.: no statistical significance; O.R.: odds ratio.