Response of human REV3 gene to gastric cancer inducing carcinogen N-methyl-N&rsquo;-nitro-N-nitrosoguanidine and its role in mutagenesis

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May 15, 2003 (publication date) through Nov 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Gastric Cancer

World J Gastroenterol. May 15, 2003; 9(5): 888-893
Published online May 15, 2003. doi: 10.3748/wjg.v9.i5.888

Table 1 Detection of the spontaneous and induced mutation frequency at HPRT locus in FL, FL-M and FL-REV3^- cells

Cell line	MNNG (0.3 µM)	Antisense block of REV3	No. of mutants per 10⁶ cells selected	Mutation frequency (10^-6)
FL	0	None	2.87	2.87
	0.3		19.25^b^c	8.66
FL-M	0	None	4.00	4
	0.3		18.75 ^b^c	18.75
FL-REV3^-	0	Yes	0^a	0
	0.3		7^a	0.14

^a: mutants screened from 5 × 10⁷ cells;

^bP < 0.01 compared with spontaneous mutants in FL cell and FL-M cell;

^cP < 0.01 compared with FL-REV3^- cells.

Citation: Zhu F, Jin CX, Song T, Yang J, Guo L, Yu YN. Response of human REV3 gene to gastric cancer inducing carcinogen N-methyl-N’-nitro-N-nitrosoguanidine and its role in mutagenesis. World J Gastroenterol 2003; 9(5): 888-893
URL: https://www.wjgnet.com/1007-9327/full/v9/i5/888.htm
DOI: https://dx.doi.org/10.3748/wjg.v9.i5.888