HLA-DRB1 allele polymorphisms in genetic susceptibility to esophageal carcinoma

Table 1 HLA-DRB1 allele frequencies in esophageal cancer patients of Hubei Han Chinese

HLA-DRB1 allels	Control group			Esophageal cancer group			P
	N1	AF(n1 = 272)	PF(n2 = 136)%	N2	AF(n1 = 84)	PF(n2 = 42)%
0101-2	13	0.0478	9.5588	2	0.0238	4.7619	> 0.05
0103	0	0.0000	0.0000	0	0.0000	0.0000
150X	46	0.1691	32.3529	9	0.1071	21.4286	> 0.05
160X	9	0.0331	6.6176	3	0.0356	7.1429	> 0.05
0301	19	0.0699	13.9706	6	0.0714	14.2857	> 0.05
0302	2	0.0074	1.4706	0	0.0000	0.0000	> 0.05
040X	30	0.1103	20.5882	12	0.1429	26.1905	> 0.05
0701-2	13	0.0478	9.5588	3	0.0357	7.1429	> 0.05
080X	22	0.0809	15.4412	4	0.0476	9.5238	> 0.05
0901	38	0.1397	26.4706	21	0.2500	45.2400	0.028*
1001	11	0.0404	7.3529	2	0.0238	4.7619	> 0.05
110X	18	0.0662	12.5000	7	0.0833	16.6667	> 0.05
120X	17	0.0625	12.5000	11	0.1310	26.1905	> 0.05
1301-2	15	0.0551	11.0294	1	0.0119	2.3810	> 0.05
1303-4	4	0.0147	2.9412	0	0.0000	0.0000	> 0.05
1305	1	0.0037	0.7353	0	0.0000	0.0000	> 0.05
1305-6	0	0.0000	0.0000	0	0.0000	0.0000
140X	15	0.0551	11.0294	3	0.0357	0.0357	> 0.05

AF: allele frequence, PF: phenotype frequence; P: Fisher,s exact test (2-tail) or χ², compared with the control with AF; *Odds ratio = 2.053, etiologic fraction = 0.12820.