Effect of leflunomide on immunological liver injury in mice

Table 4 Influences of leflunomide in vivo on IL-1 and IL-2 production and splenocyte proliferation in mice induced by BCG+LPS. (unit:10³cpm) (n = 8, ^-x ± s)

Groups	Dose (mg·kg-1)	IL-1	IL-2	Splenocyte proliferation
Normal		11.2 ± 2.40	13.3 ± 1.76	17.5 ± 2.26
Model		34.6 ± 3.96d	9.3 ± 1.57d	7.9 ± 1.19d
Leflunomide	4	29.6 ± 3.71ad	8.2 ± 1.44d	7.0 ± 1.01d
	12	18.9 ± 3.28bd	7.6 ± 1.31ad	6.4 ± 0.95ad
	36	16.6 ± 3.08bd	6.5 ± 1.20bd	5.2 ± 0.87bd
Prednisone	3	15.7 ± 2.85bd	5.0 ± 1.12bd	4.4 ± 0.71bd

^aP<0.05,

^bP<0.01 vs model group;

^dP<0.01 vs normal group.