Basic Research
Copyright ©The Author(s) 2003.
World J Gastroenterol. Feb 15, 2003; 9(2): 320-323
Published online Feb 15, 2003. doi: 10.3748/wjg.v9.i2.320
Table 2 Effects of leflunomide on serum NO, MDA and GSHpx contents in liver homogenates induced by BCG+LPS in mice (n = 10, -x ± s)
GroupsDose (mg·kg-1)PlasmaNO (μM)Liver homogenates
MDA (nmol/g tissue)GSHpx (μ/mg protein)
Normal8.8 ± 1.0133.2 ± 14.5163.9 ± 15.9
Model74.5 ± 10.1d395.9 ± 23.6d62.5 ± 8.8d
Leflunomide468.3 ± 8.5d385.7 ± 22.2d66.3 ± 9.1d
1260.7 ± 7.1bd363.9 ± 19.3bd87.1 ± 9.9bd
3655.3 ± 6.2bd301.9 ± 17.1bd95.1 ± 10.7bd
Prednisone344.4 ± 5.3bd272.0 ± 15.7bd108.0 ± 12.0bd