Effect of leflunomide on immunological liver injury in mice

Table 1 Effects of leflunomide on serum ALT and AST activities induced by BCG+LPS in mice (n = 10, ^-x ± s)

Groups Dose	(mg·kg-1)	ALT (u·L-1)	AST (u·L-1)
Normal		32.1 ± 5.6	35.8 ± 6.4
Model		195.4 ± 21.8d	188.4 ± 22.5d
Leflunomide	4	181.5 ± 19.5d	175.2 ± 18.1d
	12	173.8 ± 15.8ad	166.5 ± 15.7ad
	36	121.8 ± 11.5bd	108.2 ± 9.8bd
Prednisone	3	81.5 ± 7.8bd	64.7 ± 5.8bd

^aP < 0.05,

^bP < 0.01 vs model group;

^dP < 0.01 vs normal group.