Epoxide hydrolase Tyr113His polymorphism is not associated with susceptibility to esophageal squamous cell carcinoma in population of North China

doi:10.3748/wjg.v9.i12.2654

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Dec 15, 2003 (publication date) through Nov 27, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Esophageal Cancer

World J Gastroenterol. Dec 15, 2003; 9(12): 2654-2657
Published online Dec 15, 2003. doi: 10.3748/wjg.v9.i12.2654

Table 2 Influence of mEH Tyr113His polymorphism on ESCC development

	Tyr/Tyr	Tyr/His + His/His	His/His	aOR(95%CI)^c	aOR (95%CI)^d
Overall
Normal	76 (30.2)	176 (69.8)	105 (41.7)
ESCC	84 (32.7)	173 (67.3)	115 (44.7)	0.756 (0.493~1.157)	1.076 (0.850~1.361)
Male
Normal	44 (30.6)	100 (69.4)	60 (41.7)
ESCC	61 (35.7)	110 (64.3)	73 (42.7)	0.724 (0.427~1.225)	1.087 (0.811~1.458)
Female
Normal	32 (29.6)	76 (70.4)	45 (41.7)
ESCC	23 (26.8)	63 (73.2)	42 (48.8)	0.825 (0.398~1.710)	1.047 (0.704~1.558)
Age ≤ 50
Normal	46 (32.6)	95 (67.4)	60 (42.6)
ESCC	19 (33.9)	37 (66.1)	22 (39.3)	0.867 (0.450~1.671)	1.064 (0.738~1.534)
Age ＞ 50
Normal	30 (27.0)	81 (73.0)	45 (40.6)
ESCC	65 (32.3)	136 (67.7)	93 (46.3)	0.790 (0.472~1.323)	1.018 (0.768~1.348)
Nonsmoker^a
Normal	31 (27.7)	81 (72.3)	49 (43.7)
ESCC	34 (28.3)	86 (71.7)	60 (50.0)	0.659 (0.338~1.286)	1.135 (0.790~1.631)
Smoker
Normal	35 (31.8)	75 (68.2)	41 (37.3)
ESCC	46 (35.4)	84 (64.6)	52 (40.0)	0.901 (0.494~1.644)	1.022 (0.728~1.433)
Negative family history^b
Normal	59 (30.9)	132 (69.1)	80 (41.9)
ESCC	49 (37.1)	83 (62.9)	51 (38.7)	0.660 (0.385~1.134)	1.237 (0.912~1.678)
Positive family history
Normal	7 (22.6)	24 (77.4)	10 (32.2)
ESCC	29 (27.9)	75 (72.1)	52 (50.0)	0.638 (0.241~1.689)	0.946 (0.546~1.639)

ESCC: esophageal squamous cell carcinoma. a,b. information of smoking status and family history was available from some of subjects. c,d. the age and sex adjusted odds ratio of Tyr/His + His/His (c) and His/His genotype (d) against Tyr/Tyr genotype.

Citation: Zhang JH, Jin X, Li Y, Wang R, Guo W, Wang N, Wen DG, Chen ZF, Kuang G, Wei LZ, Wang SJ. Epoxide hydrolase Tyr113His polymorphism is not associated with susceptibility to esophageal squamous cell carcinoma in population of North China. World J Gastroenterol 2003; 9(12): 2654-2657
URL: https://www.wjgnet.com/1007-9327/full/v9/i12/2654.htm
DOI: https://dx.doi.org/10.3748/wjg.v9.i12.2654