Epoxide hydrolase Tyr113His polymorphism is not associated with susceptibility to esophageal squamous cell carcinoma in population of North China

doi:10.3748/wjg.v9.i12.2654

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Dec 15, 2003 (publication date) through Nov 30, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Esophageal Cancer

World J Gastroenterol. Dec 15, 2003; 9(12): 2654-2657
Published online Dec 15, 2003. doi: 10.3748/wjg.v9.i12.2654

Table 1 Demographic characteristics and mEH Tyr113His polymorphism in ESCC patients and healthy individuals

Groups	Control n (%)	ESCC n (%)
Sex
Male	147 (58.3)	171 (66.5)
Female	105 (41.7)	86 (33.5)
Age (mean ± SD)	49.4 ± 8.56	58.5 ± 9.39
Smoking status^a
Ex-or current smoker	110 (49.5)	130 (52.0)
Non-smoker	112 (50.5)	120 (48.0)
Family history of UGIC^b
Positive	31 (14.0)	104 (44.1)
Negative	191 (86.0)	132 (55.9)
Genotype
Tyr/Tyr	76 (30.2)	49 (37.1)
Tyr/His	71 (28.2)	32 (24.2)
His/His	105 (41.6)	51 (38.7)
Allele type
T	223 (44.2)	226 (44.0)
C	281 (55.8)	288 (56.0)

ESCC: esophageal squamous cell carcinoma, UGIC: upper gas-trointestinal cancer. a. Information of smoking status was avail-able from some of subjects, b. Positive family history of UGIC significantly increased the risk to develop ESCC. Age and sex adjusted OR = 4.06 (95%CI = 2.46-6.69), χ² = 49.87, P < 0.0001.

Citation: Zhang JH, Jin X, Li Y, Wang R, Guo W, Wang N, Wen DG, Chen ZF, Kuang G, Wei LZ, Wang SJ. Epoxide hydrolase Tyr113His polymorphism is not associated with susceptibility to esophageal squamous cell carcinoma in population of North China. World J Gastroenterol 2003; 9(12): 2654-2657
URL: https://www.wjgnet.com/1007-9327/full/v9/i12/2654.htm
DOI: https://dx.doi.org/10.3748/wjg.v9.i12.2654