Diagnostic value of platelet derived growth factor-BB, transforming growth factor-β1, matrix metalloproteinase-1, and tissue inhibitor of matrix metalloproteinase-1 in serum and peripheral blood mononuclear cells for hepatic fibrosis

Table 5 ROC curve analysis of nine indices

Index	AUC	P	Cut-off point	Sensitivity (%)	Specificity (%)	YI
PDGF-BB	0.985	0.000	≥40.50 ng/L	90.0	95.0	0.850
TIMP-1mRNA	0.876	0.000	≥0.79	73.7	100	0.737
TIMP-1mRNA/MMP-1mRNA	0.792	0.005	≥3.20	65.8	100	0.658
TIMP-1/MMP-1	0.748	0.001	≥34.69	70.0	75.0	0.450
HA	0.728	0.003	≥145.20 μg/L	62.0	87.5	0.497
PCIII	0.727	0.004	≥137.40 mg/L	59.2	81.2	0.404
TIMP-1	0.726	0.003	≥254.00 μg/L	46.7	95.0	0.417
CIV	0.583	0.287	≥74.20 mg/L	55.1	68.7	0.238
LN	0.463	0.636	≥156.65 μg/L	37.8	75.0	0.128

YI (Youden Index) = sensitivity + specificity-1.