Segregation analysis of hepatocellular carcinoma in a moderately high-incidence area of East China

Table 5 Complex segregation analysis on HCC among the 210 extended pedigrees (SAGE-REGTL, model 1)

Parametera	Hypothesis
	Mendelian			Majorgene	Environmental	Notransmission	General
	Dominant	Recessive	Additive
qA	0.00304	0.11138	0.11451	0.87964	0.02229	0b	0.00861
τAA	1.0b	1.0b	1.0b	1.0b	1.0c	0b	1.0c
τAB	0.5b	0.5b	0.5b	0.5b	1.0c	0b	0.0c
τBB	0b	0b	0b	0b	1.0c	0b	1.0c
βAA	-5.74896	-6.86219	-7.30081	-13.664	-7.27445	-6.74403	-9.22295
βAB	-5.74896d	-14.22974	-14.45292	-22.64140	-4.14230	-6.74403d	-6.19460
βBB	-11.62577	-14.22974d	-21.60502	-6.83546	-9.94049	-6.74403d	-20.47273
α	0.10039	0.12335	0.12867	0.12385	0.07499	0.05710	0.08464
γ	0.72125	1.000c	0.86915	1.000c	0.89922	1.000c	1.000c
ζHBsAg	0.93155	1.36380	1.84008	1.20200	2.72339	2.70874	1.47535
-2lnL	831.07918	799.68716	805.17010	798.20661	822.20467	842.79594	803.24635
AIC	843.07918	811.68716	817.17010	812.20661	838.20467	850.79594	825.24635
χ²	27.83283	3.55919	1.92375	5.03974	18.95832	39.54959
dfe	1-5	2-5	1-5	1-4	2-3	4-7
Pvalue	P < 0.001	P > 0.1	P > 0.1	0.01 < P < 0.03	P < 0.001	P < 0.001

a: See Materials and Methods for definitions of the parameters. b: Parameter was fixed at this value and estimation was not carried out. c: Parameter estimate reached its bound. d: Parameter was constrained to equal the preceding one and was not estimated. e: Range in degrees of freedom was given since parameters in models reached their bounds.